University of Oulu

Bioresorbable plain and ciprofloxacin-releasing self-reinforced PLGA 80/20 implants' suitability for craniofacial surgery : histological and mechanical assessment

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Author: Tiainen, Johanna1,2
Organizations: 1University of Oulu, Faculty of Medicine, Department of Surgery
2Oulu University Hospital
Format: ebook
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.8 MB)
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Language: English
Published: 2007
Publish Date: 2007-11-06
Thesis type: Doctoral Dissertation
Defence Note: Academic Dissertation to be presented, with the assent of the Faculty of Medicine of the University of Oulu, for public defence in Auditorium 1 of Oulu University Hospital, on November 16th, 2007, at 12 noon
Reviewer: Professor Alicia El Haj
Professor Yrjö T. Konttinen


Ciprofloxacin was incorporated to plain bioresorbable self-reinforced polylactide/glycolyde 80/20 screws and tacks (ciprofloxacin releasing SR-PLGA). These implants were compared to otherwise similar conventional fixation devices. The effect of the ciprofloxacin addition on the pull-out force of screws and tacks was evaluated in human cadaver cranial bones. SR-PLGA tacks applied to cranial bone with a special applicator gun had a similar holding power as screws. Addition of the antibiotic compromised the strength of the screws so that ciprofloxacin-containing PLGA screws had lower pull-out strength than corresponding plain PLGA screws. Scanning electron microscopy showed that the fibrillar strip-like microstructure of plain SR-PLGA screws turned into a coarse uni-axial platelet-like pattern as a result of ciprofloxacin addition. It is concluded that this type of 4 mm long and 1.5 mm diameter ciprofloxacin-containing screws can only be used in non-load-bearing or slightly load-bearing applications. Tissue reactions elicited by plain bioresorbable self-reinforced polylactide/glycolide (SR-PLGA) 80/20 screws were compared to similar but ciprofloxacin-releasing SR-PLGA fixation devices in rabbit cranial bone. Plain and ciprofloxacin-PLGA 80/20 screws elicited only mild inflammatory reactions upon implantation in rabbit cranial bone, but they did not interfere with osteoblast activity in up to 72 week long follow-up. Release of the antibiotic from ciprofloxacin-PLGA screws was gradual and the drug concentration in bone tissues was still higher at 8 weeks than the minimal inhibitory concentration (MIC) of ciprofloxacin for S. aureus (0.1–1.0 μg/g). Ciprofloxacin-releasing SR-PLGA screws can find clinical usage in the prevention of implant-related infections in osteofixation in craniomaxillofacial bones in non-load-bearing or slightly load-bearing applications. Larger 6 mm long and 2 mm diameter ciprofloxacin-releasing tacks had a similar holding power to cranial bone as conventional tacks. Tacks can be recommended for clinical use as the application procedure saves time and costs.

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Series: Acta Universitatis Ouluensis. D, Medica
ISSN-E: 1796-2234
ISBN: 978-951-42-8576-9
ISBN Print: 978-951-42-8575-2
Issue: 945
Copyright information: © University of Oulu, 2007. This publication is copyrighted. You may download, display and print it for your own personal use. Commercial use is prohibited.