University of Oulu

Lassi Rieppo, Juha Töyräs & Simo Saarakkala (2016): Vibrational spectroscopy of articular cartilage, Applied Spectroscopy Reviews, DOI: 10.1080/05704928.2016.1226182

Vibrational spectroscopy of articular cartilage

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Author: Rieppo, Lassi1,2; Töyräs, Juha2,3; Saarakkala, Simo1,4,5
Organizations: 1Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
2Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
3Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland
4Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finlan
5Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.9 MB)
Persistent link:
Language: English
Published: Informa, 2016
Publish Date: 2016-12-15


Articular cartilage is a connective tissue that is located at the ends of long bones. Type II collagen, proteoglycans, water, and chondrocytes are the main constituents of articular cartilage. Osteoarthritis, the most common joint disease in the world, causes degenerative changes in articular cartilage tissue. Fourier transform infrared (FTIR), Raman, and near infrared (NIR) spectroscopic techniques offer versatile tools to assess biochemical composition and quality of articular cartilage. These vibrational spectroscopic techniques can be used to broaden our understanding about the compositional changes during osteoarthritis, and they also hold promise in disease diagnostics. In this article, the current literature of articular cartilage spectroscopic studies is reviewed.

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Series: Applied spectroscopy reviews
ISSN: 0570-4928
ISSN-E: 1520-569X
ISSN-L: 0570-4928
Pages: 1 - 18
DOI: 10.1080/05704928.2016.1226182
Type of Publication: A2 Review article in a scientific journal
Field of Science: 114 Physical sciences
116 Chemical sciences
217 Medical engineering
3111 Biomedicine
Funding: Academy of Finland (grant no. 268378), European Research Councilunder the European Union ’s Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement no. 336267
EU Grant Number: (336267) 3D-OA-HISTO - Development of 3D Histopathological Grading of Osteoarthritis
Academy of Finland Grant Number: 268378
Detailed Information: 268378 (Academy of Finland Funding decision)
Copyright information: © 2016 Authors. Association of American Geographers© Lassi Rieppo, Juha Töyräs, and Simo Saarakkala This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.