University of Oulu

Podlipská, J., Guermazi, A., Lehenkari, P. et al. Comparison of Diagnostic Performance of Semi-Quantitative Knee Ultrasound and Knee Radiography with MRI: Oulu Knee Osteoarthritis Study. Sci Rep 6, 22365 (2016).

Comparison of diagnostic performance of semi-quantitative knee ultrasound and knee radiography with MRI : Oulu knee osteoarthritis study

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Author: Podlipská, Jana1; Guermazi, Ali2; Lehenkari, Petri3;
Organizations: 1Research Unit of Medical Imaging, Physics and Technology, Infotech Oulu, University of Oulu, Oulu, Finland
2Department of Radiology, Boston University School of Medicine, Boston, MA, USA
3Departments of Anatomy and Surgery Clinic, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.
4Research Unit of Medical Imaging, Physics and Technology, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
5Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
6Department of Radiology, University of Erlangen- Nuremberg, Erlangen, Germany
7Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
8Department of Physical and Rehabilitation Medicine, Kuopio University Hospital, Kuopio, Finland
9Department of Internal Medicine, Mikkeli Central Hospital, Mikkeli, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1 MB)
Persistent link:
Language: English
Published: Springer Nature, 2016
Publish Date: 2016-12-14


Osteoarthritis (OA) is a common degenerative musculoskeletal disease highly prevalent in aging societies worldwide. Traditionally, knee OA is diagnosed using conventional radiography. However, structural changes of articular cartilage or menisci cannot be directly evaluated using this method. On the other hand, ultrasound is a promising tool able to provide direct information on soft tissue degeneration. The aim of our study was to systematically determine the site-specific diagnostic performance of semi-quantitative ultrasound grading of knee femoral articular cartilage, osteophytes and meniscal extrusion, and of radiographic assessment of joint space narrowing and osteophytes, using MRI as a reference standard. Eighty asymptomatic and 79 symptomatic subjects with mean age of 57.7 years were included in the study. Ultrasound performed best in the assessment of femoral medial and lateral osteophytes, and medial meniscal extrusion. In comparison to radiography, ultrasound performed better or at least equally well in identification of tibio-femoral osteophytes, medial meniscal extrusion and medial femoral cartilage morphological degeneration. Ultrasound provides relevant additional diagnostic information on tissue-specific morphological changes not depicted by conventional radiography. Consequently, the use of ultrasound as a complementary imaging tool along with radiography may enable more accurate and cost-effective diagnostics of knee osteoarthritis at the primary healthcare level.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 6
Pages: 1 - 12
Article number: srep22365
DOI: 10.1038/srep22365
Type of Publication: A1 Journal article – refereed
Field of Science: 3126 Surgery, anesthesiology, intensive care, radiology
3141 Health care science
3142 Public health care science, environmental and occupational health
318 Medical biotechnology
Funding: We acknowledge the financial support of University of Oulu (strategic funding), Academy of Finland (grant 268378), Radiological Society of Finland, and International Doctoral Programme in Biomedical Engineering and Medical Physics (funded by Ministry of Education and Culture and Academy of Finland).
Academy of Finland Grant Number: 268378
Detailed Information: 268378 (Academy of Finland Funding decision)
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