University of Oulu

Tuovinen T, Rytty R, Moilanen V, Abou Elseoud A, Veijola J, Remes AM and Kiviniemi VJ (2017) The Effect of Gray Matter ICA and Coefficient of Variation Mapping of BOLD Data on the Detection of Functional Connectivity Changes in Alzheimer’s Disease and bvFTD. Front. Hum. Neurosci. 10:680. doi: 10.3389/fnhum.2016.00680

The effect of gray matter ICA and coefficient of variation mapping of BOLD data on the detection of functional connectivity changes in Alzheimer’s disease and bvFTD

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Author: Tuovinen, Timo1,2,3; Rytty, Riikka1,2,3,4; Moilanen, Virpi4;
Organizations: 1Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
2Oulu Functional NeuroImaging group, Research Unit of Medical Imaging, Physics and Technology, the Faculty of Medicine, University of Oulu, Oulu, Finland
3Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland
4Research Unit of Clinical Neuroscience, Faculty of Medicine, University of Oulu, Oulu, Finland
5Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
6Department of Neurology, Kuopio University Hospital, Kuopio, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.2 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe201702201788
Language: English
Published: Frontiers Media, 2017
Publish Date: 2017-02-20
Description:

Abstract

Resting-state fMRI results in neurodegenerative diseases have been somewhat conflicting. This may be due to complex partial volume effects of CSF in BOLD signal in patients with brain atrophy. To encounter this problem, we used a coefficient of variation (CV) map to highlight artifacts in the data, followed by analysis of gray matter voxels in order to minimize brain volume effects between groups. The effects of these measures were compared to whole brain ICA dual regression results in Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD). 23 AD patients, 21 bvFTD patients and 25 healthy controls were included. The quality of the data was controlled by CV mapping. For detecting functional connectivity (FC) differences whole brain ICA (wbICA) and also segmented gray matter ICA (gmICA) followed by dual regression were conducted, both of which were performed both before and after data quality control. Decreased FC was detected in posterior DMN in the AD group and in the Salience network in the bvFTD group after combining CV quality control with gmICA. Before CV quality control, the decreased connectivity finding was not detectable in gmICA in neither of the groups. Same finding recurred when exclusion was based on randomization. The subjects excluded due to artifacts noticed in the CV maps had significantly lower temporal signal-to-noise ratio than the included subjects. Data quality measure CV is an effective tool in detecting artifacts from resting state analysis. CV reflects temporal dispersion of the BOLD signal stability and may thus be most helpful for spatial ICA, which has a blind spot in spatially correlating widespread artifacts. CV mapping in conjunction with gmICA yields results suiting previous findings both in AD and bvFTD.

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Series: Frontiers in human neuroscience
ISSN: 1662-5161
ISSN-E: 1662-5161
ISSN-L: 1662-5161
Volume: 10
Article number: 680
DOI: 10.3389/fnhum.2016.00680
OADOI: https://oadoi.org/10.3389/fnhum.2016.00680
Type of Publication: A1 Journal article – refereed
Field of Science: 3112 Neurosciences
Subjects:
Funding: This work was supported by grants from Finnish Academy grants 117111 and 123772 (VK), Finnish Medical Foundation (VK, AR, and TT), Finnish Neurological Foundation (VK), KEVO grants from Oulu University hospital (VK, AR), National Graduate School of Clinical Investigation (RR), Finnish Brain Foundation (RR).
Academy of Finland Grant Number: 117111
123772
Detailed Information: 117111 (Academy of Finland Funding decision)
123772 (Academy of Finland Funding decision)
Copyright information: © 2017 Tuovinen, Rytty, Moilanen, Abou Elseoud, Veijola, Remes and Kiviniemi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
  https://creativecommons.org/licenses/by/4.0/