University of Oulu

Christian Appenzeller-Herzog, Gabor Bánhegyi, Ivan Bogeski, Kelvin J.A. Davies, Agnès Delaunay-Moisan, Henry Jay Forman, Agnes Görlach, Thomas Kietzmann, Francisco Laurindo, Eva Margittai, Andreas J. Meyer, Jan Riemer, Michael Rützler, Thomas Simmen, Roberto Sitia, Michel B. Toledano, Ivo P. Touw, Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish, Free Radical Biology and Medicine, Volume 94, May 2016, Pages 157-160, ISSN 0891-5849, http://dx.doi.org/10.1016/j.freeradbiomed.2016.02.030.

Transit of H₂O₂ across the endoplasmic reticulum membrane is not sluggish

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Author: Appenzeller-Herzog, Christian1; Bánhegyi, Gabor2; Bogeski, Ivan3;
Organizations: 1Berufsfachschule Gesundheit Baselland, 4142 Münchenstein, Switzerland
2Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest 1428, Hungary
3Department of Biophysics, School of Medicine, University of Saarland, 66421 Homburg, Germany
4Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center; and Division of Molecular and Computational Biology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, The University of Southern California, Los Angeles, CA 90089-0191, USA
5Division of Molecular and Computational Biology, Department of Biological Sciences, Dornsife College of Letters, Arts, and Sciences, The University of Southern California, Los Angeles, CA 90089-0191, USA
6Laboratoire Stress Oxydant et Cancers, CEA-Saclay, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif sur Yvette Cedex, France
7Experimental and Molecular Pediatric Cardiology, German Heart Center Munich at the TU Munich, 80636 Munich, Germany
8Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90210 Oulu, Finland
9Vascular Biology Laboratory, Heart Institute, University of São Paulo School of Medicine, CEP 05403-000 São Paulo, Brazil
10Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest 1428, Hungary
11NRES-Chemical Signalling, University of Bonn, 53113 Bonn, Germany
12Institute for Biochemistry, University of Cologne, 50674 Cologne, Germany
13Institute for Health Science and Technology, Aalborg University, DK-9220 Aalborg, Denmark
14Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G2H7
15Protein Transport and Secretion Unit, Division of Genetics and Cell Biology, IRCCS, Ospedale San Raffaele/Universita‘ Vita-Salute San Raffaele, 20132 Milan, Italy
16Erasmus University Medical Center, Department of Hematology, PO Box 2040, Rotterdam, The Netherlands
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.9 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe201703021950
Language: English
Published: Elsevier, 2016
Publish Date: 2017-03-02
Description:

Abstract

Cellular metabolism provides various sources of hydrogen peroxide (H₂O₂) in different organelles and compartments. The suitability of H₂O₂ as an intracellular signaling molecule therefore also depends on its ability to pass cellular membranes. The propensity of the membranous boundary of the endoplasmic reticulum (ER) to let pass H₂O₂ has been discussed controversially. In this essay, we challenge the recent proposal that the ER membrane constitutes a simple barrier for H₂O₂ diffusion and support earlier data showing that (i) ample H₂O₂ permeability of the ER membrane is a prerequisite for signal transduction, (ii) aquaporin channels are crucially involved in the facilitation of H₂O₂ permeation, and (iii) a proper experimental framework not prone to artifacts is necessary to further unravel the role of H₂O₂ permeation in signal transduction and organelle biology.

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Series: Free radical biology and medicine
ISSN: 0891-5849
ISSN-L: 0891-5849
Volume: 94
Pages: 157 - 160
Article number: S0891584916000897
DOI: 10.1016/j.freeradbiomed.2016.02.030
OADOI: https://oadoi.org/10.1016/j.freeradbiomed.2016.02.030
Type of Publication: A1 Journal article – refereed
Field of Science: 1182 Biochemistry, cell and molecular biology
Subjects:
Copyright information: © 2016 Elsevier Inc. All rights reserved.