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Transit of H₂O₂ across the endoplasmic reticulum membrane is not sluggish |
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| Author: | Appenzeller-Herzog, Christian1; Bánhegyi, Gabor2; Bogeski, Ivan3; |
| Organizations: |
1Berufsfachschule Gesundheit Baselland, 4142 Münchenstein, Switzerland 2Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest 1428, Hungary 3Department of Biophysics, School of Medicine, University of Saarland, 66421 Homburg, Germany
4Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center; and Division of Molecular and Computational Biology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, The University of Southern California, Los Angeles, CA 90089-0191, USA
5Division of Molecular and Computational Biology, Department of Biological Sciences, Dornsife College of Letters, Arts, and Sciences, The University of Southern California, Los Angeles, CA 90089-0191, USA 6Laboratoire Stress Oxydant et Cancers, CEA-Saclay, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif sur Yvette Cedex, France 7Experimental and Molecular Pediatric Cardiology, German Heart Center Munich at the TU Munich, 80636 Munich, Germany 8Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90210 Oulu, Finland 9Vascular Biology Laboratory, Heart Institute, University of São Paulo School of Medicine, CEP 05403-000 São Paulo, Brazil 10Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest 1428, Hungary 11NRES-Chemical Signalling, University of Bonn, 53113 Bonn, Germany 12Institute for Biochemistry, University of Cologne, 50674 Cologne, Germany 13Institute for Health Science and Technology, Aalborg University, DK-9220 Aalborg, Denmark 14Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G2H7 15Protein Transport and Secretion Unit, Division of Genetics and Cell Biology, IRCCS, Ospedale San Raffaele/Universita‘ Vita-Salute San Raffaele, 20132 Milan, Italy 16Erasmus University Medical Center, Department of Hematology, PO Box 2040, Rotterdam, The Netherlands |
| Format: | article |
| Version: | accepted version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.9 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe201703021950 |
| Language: | English |
| Published: |
Elsevier,
2016
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| Publish Date: | 2017-03-02 |
| Description: |
AbstractCellular metabolism provides various sources of hydrogen peroxide (H₂O₂) in different organelles and compartments. The suitability of H₂O₂ as an intracellular signaling molecule therefore also depends on its ability to pass cellular membranes. The propensity of the membranous boundary of the endoplasmic reticulum (ER) to let pass H₂O₂ has been discussed controversially. In this essay, we challenge the recent proposal that the ER membrane constitutes a simple barrier for H₂O₂ diffusion and support earlier data showing that (i) ample H₂O₂ permeability of the ER membrane is a prerequisite for signal transduction, (ii) aquaporin channels are crucially involved in the facilitation of H₂O₂ permeation, and (iii) a proper experimental framework not prone to artifacts is necessary to further unravel the role of H₂O₂ permeation in signal transduction and organelle biology. see all
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| Series: |
Free radical biology & medicine |
| ISSN: | 0891-5849 |
| ISSN-E: | 1873-4596 |
| ISSN-L: | 0891-5849 |
| Volume: | 94 |
| Pages: | 157 - 160 |
| Article number: | S0891584916000897 |
| DOI: | 10.1016/j.freeradbiomed.2016.02.030 |
| OADOI: | https://oadoi.org/10.1016/j.freeradbiomed.2016.02.030 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
1182 Biochemistry, cell and molecular biology |
| Subjects: | |
| Copyright information: |
© 2016 Elsevier Inc. All rights reserved. |