University of Oulu

Kati Richter, Anja Konzack, Taina Pihlajaniemi, Ritva Heljasvaara, Thomas Kietzmann, Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences, Redox Biology, Volume 6, December 2015, Pages 344-352, ISSN 2213-2317,

Redox-fibrosis : impact of TGFβ1 on ROS generators, mediators and functional consequences

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Author: Richter, Kati1; Konzack, Anja1; Pihlajaniemi , Taina1,2;
Organizations: 1Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, Oulu, Finland
2Center of Excellence in Cell-Extracellular Matrix Research, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.3 MB)
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Language: English
Published: Elsevier, 2015
Publish Date: 2017-03-13


Fibrosis is one of the most prevalent features of age-related diseases like obesity, diabetes, non-alcoholic fatty liver disease, chronic kidney disease, or cardiomyopathy and affects millions of people in all countries. Although the understanding about the pathophysiology of fibrosis has improved a lot during the recent years, a number of mechanisms still remain unknown. Although TGF-β1 signaling, loss of metabolic homeostasis and chronic low-grade inflammation appear to play important roles in the pathogenesis of fibrosis, recent evidence indicates that oxidative stress and the antioxidant system may also be crucial for fibrosis development and persistence. These findings point to a concept of a redox-fibrosis where the cellular oxidant and antioxidant system could be potential therapeutic targets. The current review aims to summarize the existing links between TGF-β1 signaling, generation and action of reactive oxygen species, expression of antioxidative enzymes, and functional consequences including epigenetic redox-mediated responses during fibrosis.

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Series: Redox biology
ISSN: 2213-2317
ISSN-E: 2213-2317
ISSN-L: 2213-2317
Volume: 6
Pages: 344 - 352
DOI: 10.1016/j.redox.2015.08.015
Type of Publication: A2 Review article in a scientific journal
Field of Science: 1182 Biochemistry, cell and molecular biology
Funding: Work of the authors is supported by Grants from the Biocenter Oulu, the Academy of Finland (251314; 2012–2017), and Sigrid Juselius Foundation. KR, AK, TK were supported by the European Cooperation in Science and Technology (COST Action BM1203/EU‐ROS)
Academy of Finland Grant Number: 251314
Detailed Information: 251314 (Academy of Finland Funding decision)
Copyright information: Under a Creative Commons license