University of Oulu

Agnes Görlach, Elitsa Y. Dimova, Andreas Petry, Antonio Martínez-Ruiz, Pablo Hernansanz-Agustín, Anabela P. Rolo, Carlos M. Palmeira, Thomas Kietzmann, Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?, Redox Biology, Volume 6, December 2015, Pages 372-385, ISSN 2213-2317,

Reactive oxygen species, nutrition, hypoxia and diseases : problems solved?

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Author: Görlach, Agnes1,2; Dimova, Elitsa Y.3; Petry, Andreas1,2;
Organizations: 1Experimental and Molecular Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Germany
2DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
3Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, Oulu, Finland
4Servicio de Immunología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa, Madrid, Spain
5Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain
6Department of Life Sciences, University of Coimbra and Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.9 MB)
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Language: English
Published: Elsevier, 2015
Publish Date: 2017-03-14


Within the last twenty years the view on reactive oxygen species (ROS) has changed; they are no longer only considered to be harmful but also necessary for cellular communication and homeostasis in different organisms ranging from bacteria to mammals. In the latter, ROS were shown to modulate diverse physiological processes including the regulation of growth factor signaling, the hypoxic response, inflammation and the immune response. During the last 60–100 years the life style, at least in the Western world, has changed enormously. This became obvious with an increase in caloric intake, decreased energy expenditure as well as the appearance of alcoholism and smoking; These changes were shown to contribute to generation of ROS which are, at least in part, associated with the occurrence of several chronic diseases like adiposity, atherosclerosis, type II diabetes, and cancer. In this review we discuss aspects and problems on the role of intracellular ROS formation and nutrition with the link to diseases and their problematic therapeutical issues.

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Series: Redox biology
ISSN: 2213-2317
ISSN-E: 2213-2317
ISSN-L: 2213-2317
Volume: 6
Pages: 372 - 385
DOI: 10.1016/j.redox.2015.08.016
Type of Publication: A2 Review article in a scientific journal
Field of Science: 1182 Biochemistry, cell and molecular biology
Funding: This work was supported by grants from German Research Foundation (DFG-GO709/4-5), DZHK (German Centre for Cardiovascular Research), German Federal Ministry of Education and Research (Acidox, Epiros), to AG. Work in the AMR lab was supported by grants from the Spanish Government (PI12/00875) and from the Fundación Domingo Martínez; AMR and PHA are supported by the I3SNS and FPU programs of the Spanish Government, respectively. Work in the TK lab was supported by grants from the Finnish Academy of Sciences, the Sigrid Juselius Foundation, CIMO, and Biocenter Oulu. Some of the authors were supported by the European Cooperation in Science and Technology (COST Action BM1203/EU‐ROS).
Copyright information: Under a Creative Commons license