University of Oulu

Cristina Espinosa-Diez, Verónica Miguel, Daniela Mennerich, Thomas Kietzmann, Patricia Sánchez-Pérez, Susana Cadenas, Santiago Lamas, Antioxidant responses and cellular adjustments to oxidative stress, Redox Biology, Volume 6, December 2015, Pages 183-197, ISSN 2213-2317,

Antioxidant responses and cellular adjustments to oxidative stress

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Author: Espinosa-Diez, Cristina1; Miguel, Verónica1; Mennerich, Daniela2;
Organizations: 1Department of Cell Biology and Immunology, Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Nicolás Cabrera 1, 28049 Madrid, Spain
2Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, Aapistie 7, University of Oulu, FI-90230 Oulu, Finland
3Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM) and Departamento de Biología Molecular, Universidad Autónoma de Madrid, Nicolás Cabrera 1, 28049 Madrid, Spain; Instituto de Investigación Sanitaria Princesa (IIS-IP), 28006 Madrid, Spain
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.9 MB)
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Language: English
Published: Elsevier, 2015
Publish Date: 2017-03-14


Redox biological reactions are now accepted to bear the Janus faceted feature of promoting both physiological signaling responses and pathophysiological cues. Endogenous antioxidant molecules participate in both scenarios. This review focuses on the role of crucial cellular nucleophiles, such as glutathione, and their capacity to interact with oxidants and to establish networks with other critical enzymes such as peroxiredoxins. We discuss the importance of the Nrf2-Keap1 pathway as an example of a transcriptional antioxidant response and we summarize transcriptional routes related to redox activation. As examples of pathophysiological cellular and tissular settings where antioxidant responses are major players we highlight endoplasmic reticulum stress and ischemia reperfusion. Topologically confined redox-mediated post-translational modifications of thiols are considered important molecular mechanisms mediating many antioxidant responses, whereas redox-sensitive microRNAs have emerged as key players in the posttranscriptional regulation of redox-mediated gene expression. Understanding such mechanisms may provide the basis for antioxidant-based therapeutic interventions in redox-related diseases.

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Series: Redox biology
ISSN: 2213-2317
ISSN-E: 2213-2317
ISSN-L: 2213-2317
Volume: 6
Pages: 183 - 197
DOI: 10.1016/j.redox.2015.07.008
Type of Publication: A2 Review article in a scientific journal
Field of Science: 1182 Biochemistry, cell and molecular biology
Funding: This work was supported by European Cooperation in Science and Research COST action BM-1203 (EU-ROS). Additional supporting grants include: Ministerio de Economía y Competitividad (MINECO) SAF 2012-31338 (SL), Instituto de Salud Carlos III REDinREN RD12/0021/0009 (SL), Comunidad de Madrid “Fibroteam” S2010/BMD-2321 (SL) and Fundación Renal “Iñigo Alvarez de Toledo” (SL), all from Spain; Biocenter Oulu, the Academy of Finland, and Sigrid Juselius Foundation, Finland (TK). The work in SC laboratory is supported by grants from the Instituto de Salud Carlos III FIS (PI12/00933) and by Comunidad de Madrid (S2011/BMD-2402) and the European Cooperation in Science and Technology (COST Action BM1203/EU‐ROS). Verónica Miguel is a fellow of the FPI-MINECO program and Patricia Sánchez-Pérez a fellow of the FPI-UAM program, Universidad Autónoma de Madrid, Spain. The CBMSO receives institutional support from Fundación “Ramón Areces”. Cristina Espinosa has been a fellow of the FPI program, MINECO, Spain.
Copyright information: Under a Creative Commons license