University of Oulu

Horbach T, Götz C, Kietzmann T and Dimova EY (2015) Protein kinases as switches for the function of upstream stimulatory factors: implications for tissue injury and cancer. Front. Pharmacol. 6:3. doi: 10.3389/fphar.2015.00003

Protein kinases as switches for the function of upstream stimulatory factors : implications for tissue injury and cancer

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Author: Horbach, Tina1,2; Götz, Claudia3; Kietzmann, Thomas1;
Organizations: 1Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, Oulu, Finland
2Department of Chemistry, University of Kaiserslautern, Kaiserslautern, Germany
3Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
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Language: English
Published: Frontiers Media, 2015
Publish Date: 2017-03-15


The upstream stimulatory factors (USFs) are regulators of important cellular processes. Both USF1 and USF2 are supposed to have major roles in metabolism, tissue protection and tumor development. However, the knowledge about the mechanisms that control the function of USFs, in particular in tissue protection and cancer, is limited. Phosphorylation is a versatile tool to regulate protein functions. Thereby, phosphorylation can positively or negatively affect different aspects of transcription factor function including protein stability, protein–protein interaction, cellular localization, or DNA binding. The present review aims to summarize the current knowledge about the regulation of USFs by direct phosphorylation and the consequences for USF functions in tissue protection and cancer.

Correction article:

Front. Pharmacol., 05 April 2016 |

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Series: Frontiers in pharmacology
ISSN: 1663-9812
ISSN-E: 1663-9812
ISSN-L: 1663-9812
Volume: 6
Article number: 3
DOI: 10.3389/fphar.2015.00003
Type of Publication: A2 Review article in a scientific journal
Field of Science: 1182 Biochemistry, cell and molecular biology
Funding: This work was supported by grants from the Wilhelm Sander Foundation (Grant 2008.043.1) to Elitsa Y. Dimova, and from CIMO, Biocenter Oulu, the Sigrid Juselius Foundation and the Finnish Academy of Science to Thomas Kietzmann.
Copyright information: Copyright © 2015 Horbach, Götz, Kietzmann and Dimova. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.