University of Oulu

Roininen, Nelli; Takala, Sari; Haapasaari, Kirsi-Maria; Jukkola-Vuorinen, Arja; Mattson, Johanna; Heikkilä, Päivi; Karihtala, Peeter. Primary neuroendocrine breast carcinomas are associated with poor local control despite favourable biological profile : a retrospective clinical study. BMC Cancer 2017 17:72. DOI: 10.1186/s12885-017-3056-4

Primary neuroendocrine breast carcinomas are associated with poor local control despite favourable biological profile : a retrospective clinical study

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Author: Roininen, Nelli1,2; Takala, Sari3; Haapasaari, Kirsi-Maria2;
Organizations: 1Department of Oncology and Radiotherapy, Medical Research Center Oulu, Oulu University Hospital and University of Oulu
2Department of Pathology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu
3Helsinki University Hospital Comprehensive Cancer Center
4Department of Pathology, University of Helsinki and Helsinki University Hospital
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe201703245825
Language: English
Published: BioMed Central, 2017
Publish Date: 2017-03-24
Description:

Abstract

Background: Breast carcinomas with neuroendocrine features (NEBC) are a very rare entity of mammary neoplasms, WHO classification of which has recently been revised. There are very limited data available about the clinical behaviour and treatment options of NEBC.

Methods: We collected retrospectively patients with NEBC from Oulu and Helsinki University Hospitals in 2007–2015. There were 43 NEBC cases during the period.

Results: The incidence of NEBC from all breast cancers varied from 0.1% in Helsinki to 1.3% in Oulu. The mean tumor size was 2.2 cm and 23 patients (55.8%) had no lymph node metastases when diagnosed. In total, 4 patients (9.3%) had distant metastases at the time of diagnosis. High estrogen receptor (ER) expression was observed in 41 (97.7%) patients. When non-metastatic NEBC were compared to a prospective set of ductal carcinomas (n = 506), NEBC were more often HER2 negative (p = 0.046), ER positive (p = 0.0062) and the NEBC patients were older (p < 0.0005) than patients with ductal carcinomas. Plasma chromogranin A correlated only to higher age at diagnosis (p = 0. 0028). Relapse-free survival (p = 0.0013), disease-free survival (p = 0.024) and overall survival (p = 0.0028) favoured ductal carcinomas compared to NEBC, while no difference was observed in distant disease-free survival or in breast cancer-specific survival.

Conclusions: There is remarkable variation in the incidence of NEBC in Finland, which is likely to be explained by differences in the use of neuroendocrine marker immunostainings. Poor local control and worse overall survival may be linked to the more aggressive biology of the disease, despite its association with apparently indolent prognostic factors.

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Series: Bmc cancer
ISSN: 1471-2407
ISSN-E: 1471-2407
ISSN-L: 1471-2407
Volume: 17
Article number: 72
DOI: 10.1186/s12885-017-3056-4
OADOI: https://oadoi.org/10.1186/s12885-017-3056-4
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
Subjects:
Funding: Thelma Mäkikyrö Foundation is acknowledged for the funding of the study.
Dataset Reference: The datasets analysed during the current study are available from the corresponding author on reasonable request. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Copyright information: © The Author(s). 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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