University of Oulu

Alvin Ibarra, Kaisa Olli, Wilrike Pasman, Henk Hendriks, Esa Alhoniemi, Ghulam Shere Raza, Karl-Heinz Herzig, Kirsti Tiihonen, Effects of polydextrose with breakfast or with a midmorning preload on food intake and other appetite-related parameters in healthy normal-weight and overweight females: An acute, randomized, double-blind, placebo-controlled, and crossover study, Appetite, Volume 110, 1 March 2017, Pages 15-24, ISSN 0195-6663, http://dx.doi.org/10.1016/j.appet.2016.12.002. (http://www.sciencedirect.com/science/article/pii/S0195666316308820) Keywords: Appetite; Energy intake; GLP-1; Insulin; Overweight; Satiation

Effects of polydextrose with breakfast or with a midmorning preload on food intake and other appetite-related parameters in healthy normal-weight and overweight females : an acute, randomized, double-blind, placebo-controlled, and crossover study

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Author: Ibarra, Alvin1,2; Olli, Kaisa1; Pasman, Wilrike3;
Organizations: 1DuPont Nutrition and Health, Kantvik, Finland
2DuPont Nutrition and Health, Danisco Sweeteners Oy, Sokeritehtaantie 20, 02460 Kantvik, Finland
3TNO, Zeist, The Netherlands
4Hendriks Nutrition Support for Business, Zeist, The Netherlands
5Avoltus Oy, Turku, Finland
6Institute of Biomedicine and Biocenter Oulu, University of Oulu, Oulu, Finland
7Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
8Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.9 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe201703305873
Language: English
Published: Elsevier, 2017
Publish Date: 2017-03-30
Description:

Abstract

Polydextrose (PDX) reduces subsequent energy intake (EI) when administered at midmorning in single-blind trials of primarily normal-weight men. However, it is unclear if this effect also occurs when PDX is given at breakfast time. Furthermore, for ecological validity, it is desirable to study a female population, including those at risk for obesity. We studied the effects of PDX, served as part of a breakfast or midmorning preload, on subsequent EI and other appetite-related parameters in healthy normal-weight and overweight females. Per earlier studies, the primary outcome was defined as the difference in subsequent EI when PDX was consumed at midmorning versus placebo. Thirty-two volunteers were enrolled in this acute, double-blind, placebo-controlled, randomized, and crossover trial to examine the effects of 12.5 g of PDX, administered as part of a breakfast or midmorning preload, on subsequent EI, subjective feelings of appetite, well-being, and mood. Gastric emptying rates and the blood concentrations of glucose, insulin, cholecystokinin, ghrelin, glucagon-like peptide 1 (GLP-1), and peptide tyrosine-tyrosine were measured in the group that received PDX as part of their breakfast. There were no differences in EI between volunteers who were fed PDX and placebo. PDX intake with breakfast tended to elevate blood glucose (P = 0.06) during the postabsorptive phase, significantly lowered insulin by 15.7% (P = 0.04), and increased GLP-1 by 39.9% (P = 0.02); no other effects on blood parameters or gastric emptying rates were observed. PDX intake at midmorning reduced hunger by 31.4% during the satiation period (P = 0.02); all other subjective feelings of appetite were unaffected. Volunteers had a uniform mood profile during the study. PDX was well tolerated, causing one mild adverse event throughout the trial.

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Volume: 110
Pages: 15 - 24
DOI: 10.1016/j.appet.2016.12.002
OADOI: https://oadoi.org/10.1016/j.appet.2016.12.002
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
Subjects:
Funding: The trial was fully sponsored by DuPont Nutrition and Health
Copyright information: © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  https://creativecommons.org/licenses/by/4.0/