University of Oulu

Gabbatore et al. Cognitive pragmatic rehabilitation program in schizophrenia : a single case fMRI study. Neural Plasticity, Volume 2017 (2017), Article ID 1612078.

Cognitive pragmatic rehabilitation program in schizophrenia : a single case fMRI study

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Author: Gabbatore, Ilaria1,2; Bosco, Francesca M.2,3,4; Geda, Elisabetta5;
Organizations: 1Faculty of Humanities, Research Unit of Logopedics, Child Language Research Center, University of Oulu, Oulu, Finland
2Center for Cognitive Science (CSC), University and Polytechnic of Turin, Turin, Italy
3Department of Psychology, University of Turin, Turin, Italy
4Neuroscience Institute of Turin, Turin, Italy
5Brain Imaging Group (BIG), KoellikerHospital, Turin, Italy
6Psychiatric Service, Mental Health Department, ASL-TO3, Turin, Italy
7CCS fMRI, Koelliker Hospital, Turin, Italy
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.4 MB)
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Language: English
Published: Hindawi, 2017
Publish Date: 2017-04-03


Introduction: The present study was intended to evaluate the effects of a rehabilitative training, the Cognitive Pragmatic Treatment (CPT), aimed at improving communicative-pragmatic abilities and the related cognitive components, on the cerebral modifications of a single case patient diagnosed with schizophrenia.

Methods: The patient underwent two functional magnetic resonance imaging (fMRI) sessions, before and after the treatment. In order to assess brain changes, we calculated the Amplitude of Low Frequency Fluctuation (ALFF) index of the resting-state fMRI signal, which is interpreted as reflecting the intensity of the spontaneous regional activity of the brain. Behavioural measures of the patient’s communicative performance were also gathered before and after training and at follow-up.

Results: The patient improved his communicative performance in almost all tests. Posttraining stronger ALFF signal emerged in the superior, inferior, and medial frontal gyri, as well as the superior temporal gyri.

Conclusions: Even if based on a single case study, these preliminary results show functional changes at the cerebral level that seem to support the patient’s behavioural improvements.

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Series: Neural plasticity
ISSN: 2090-5904
ISSN-E: 1687-5443
ISSN-L: 2090-5904
Volume: 2017
Article number: 1612078
DOI: 10.1155/2017/1612078
Type of Publication: A1 Journal article – refereed
Field of Science: 515 Psychology
3112 Neurosciences
3124 Neurology and psychiatry
520 Other social sciences
Funding: The research was funded byMIUR PRIN (Progetti di Ricerca di Rilevante Interesse Nazionale) 2017, project “The Interpretative Brain: Understanding and Promoting Pragmatic Abilities across Lifespan and in Mental Illness,” project code 201577HA9M.
Copyright information: Copyright © 2017 Ilaria Gabbatore et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.