University of Oulu

D. A. Barskiy, A. M. Coffey, P. Nikolaou, D. M. Mikhaylov, B. M. Goodson, R. T. Branca, G. J. Lu, M. G. Shapiro, V.-V. Telkki, V. V. Zhivonitko, I. V. Koptyug, O. G. Salnikov, K. V. Kovtunov, V. I. Bukhtiyarov, M. S. Rosen, M. J. Barlow, S. Safavi, I. P. Hall, L. Schröder, E. Y. Chekmenev, Chem. Eur. J. 2017, 23, 725

NMR hyperpolarization techniques of gases

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Author: Barskiy, Danila A.1; Coffey, Aaron M.1; Nikolaou, Panayiotis1;
Organizations: 1Department of Radiology, Department of Biomedical Engineering, Department of Physics, Vanderbilt-Ingram Cancer Center (VICC), Vanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University, Nashville, TN, USA
2Huazhong University of Science and Technology, Wuhan, China
3Southern Illinois University, Department of Chemistry and Biochemistry, Materials Technology Center, Carbondale, IL, USA
4Department of Physics and Astronomy, Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
5Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA
6NMR Research Unit, University of Oulu, Oulu, Finland
7International Tomography Center SB RAS, Novosibirsk, Russia
8Novosibirsk State University, Novosibirsk, Russia
9Boreskov Institute of Catalysis SB RAS, Novosibirsk, Russia
10MGH/A.A. Martinos Center for Biomedical Imaging, Boston, MA, USA
11Respiratory Medicine Department, Queen's Medical Centre, University of Nottingham Medical School, Nottingham, UK
12Molecular Imaging, Department of Structural Biology, Leibniz-Institut für Molekulare Pharmakologie (FMP), Berlin, Germany
13Russian Academy of Sciences, Moscow, Russia
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 4.7 MB)
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Language: English
Published: John Wiley & Sons, 2017
Publish Date: 2017-12-05


Nuclear spin polarization can be significantly increased through the process of hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance (NMR) experiments by 4–8 orders of magnitude. Hyperpolarized gases, unlike liquids and solids, can often be readily separated and purified from the compounds used to mediate the hyperpolarization processes. These pure hyperpolarized gases enabled many novel MRI applications including the visualization of void spaces, imaging of lung function, and remote detection. Additionally, hyperpolarized gases can be dissolved in liquids and can be used as sensitive molecular probes and reporters. This Minireview covers the fundamentals of the preparation of hyperpolarized gases and focuses on selected applications of interest to biomedicine and materials science.

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Series: Chemistry. A European journal
ISSN: 0947-6539
ISSN-E: 1521-3765
ISSN-L: 0947-6539
Volume: 23
Issue: 4
Pages: 725 - 751
DOI: 10.1002/chem.201603884
Type of Publication: A2 Review article in a scientific journal
Field of Science: 114 Physical sciences
116 Chemical sciences
Funding: The Hyperpolarised Lung Function Imaging Facility (HILF), within the Sir Peter Mansfield Magnetic Imaging Centre (SPMIC) at University of Nottingham, where the M.J.B, SS and IPH undertake research into novel functional MRI techniques, is the beneficiary of grants provided by UK’s Medical Research Council (MRC) and Engineering and Physical Sciences Research Council (EPSRC). MGS thanks Burroughs Wellcome Fund Career Award at the Scientific Interface, Human Frontiers Science Program #RGP0050, and Heritage Medical Research Institute for funding. AMC thanks NIH 1F32EB021840 career award. We thank the following award for funding support: NSF CHE-1416268 and CHE-1416432 (EYC, BMG, IVK, KVK), NIH 1R21EB018014 and 1R21EB020323 (EYC and BMG), DOD CDMRP BRP W81XWH-12-1-0159/BC112431 (EYC), PRMRP W81XWH-15-1-0271 and W81XWH-15-1-0272 (EYC, MSR, BMG), ExxonMobil Research and Engineering Company Knowledge Build (EYC). KVK, VVZ and IVK thank the Russian Science Foundation (grant 14–35–00020) for support of the MRI experiments. V.-V.T. acknowledges the Academy of Finland (grant numbers 289649 and 294027) for the financial support. Part of this work has been supported by the European Research Council under the European Community’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. 242710 to L.S.) and the Leibniz Association (WGL; grant SAW-2011-FMP-2 to L.S.).
Academy of Finland Grant Number: 289649
Detailed Information: 289649 (Academy of Finland Funding decision)
294027 (Academy of Finland Funding decision)
Copyright information: © 2017 Wiley-VCH Verlag GmbH &Co. KGaA, Weinheim. Published in this repository with the kind permission of the publisher.