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Bucharskaya, A.; Maslyakova, G.; Terentyuk, G.; Yakunin, A.; Avetisyan, Y.; Bibikova, O.; Tuchina, E.; Khlebtsov, B.; Khlebtsov, N.; Tuchin, V. Towards Effective Photothermal/Photodynamic Treatment Using Plasmonic Gold Nanoparticles. Int. J. Mol. Sci. 2016, 17, 1295.

Towards effective photothermal/photodynamic treatment using plasmonic gold nanoparticles

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Author: Bucharskaya, Alla1; Maslyakova, Galina1; Terentyuk, Georgy1,2;
Organizations: 1Research Institute for Fundamental and Clinical Uronephrology, Saratov State Medical University, n.a. V.I. Razumovsky, 410012 Saratov, Russia
2Research-Education Institute of Optics and Biophotonics, Saratov National Research State University, 410012 Saratov, Russia
3Institute of Precision Mechanics and Control, RAS, 410028 Saratov, Russia
4Artphotonics GmbH, 12489 Berlin, Germany
5Optoelectronics and Measurement Techniques Laboratory, University of Oulu, 90014 Oulu, Finland
6Institute of Analytical and Bioanalytical Chemistry, Ulm University, 89081 Ulm, Germany
7Department of Biology, Saratov National Research State University, 410012 Saratov, Russia
8Institute of Biochemistry and Physiology of Plants and Microorganisms, RAS, 410049 Saratov, Russia
9Department of Nano- and Biomedical Technologies, Saratov National Research State University, 410012 Saratov, Russia
10Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, 634050 Tomsk, Russia
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 7.4 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe201704266266
Language: English
Published: Multidisciplinary Digital Publishing Institute, 2016
Publish Date: 2017-04-26
Description:

Abstract

Gold nanoparticles (AuNPs) of different size and shape are widely used as photosensitizers for cancer diagnostics and plasmonic photothermal (PPT)/photodynamic (PDT) therapy, as nanocarriers for drug delivery and laser-mediated pathogen killing, even the underlying mechanisms of treatment effects remain poorly understood. There is a need in analyzing and improving the ways to increase accumulation of AuNP in tumors and other crucial steps in interaction of AuNPs with laser light and tissues. In this review, we summarize our recent theoretical, experimental, and pre-clinical results on light activated interaction of AuNPs with tissues and cells. Specifically, we discuss a combined PPT/PDT treatment of tumors and killing of pathogen bacteria with gold-based nanocomposites and atomic clusters, cell optoporation, and theoretical simulations of nanoparticle-mediated laser heating of tissues and cells.

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Series: International journal of molecular sciences
ISSN: 1661-6596
ISSN-E: 1422-0067
ISSN-L: 1661-6596
Volume: 17
Issue: 8
Pages: 1 - 26
DOI: 10.3390/ijms17081295
OADOI: https://oadoi.org/10.3390/ijms17081295
Type of Publication: A2 Review article in a scientific journal
Field of Science: 1182 Biochemistry, cell and molecular biology
Subjects:
Au nanoparticles
cell optoporation
nanocomposites
nanorods
nanostars
pathogens
photodynamic therapy (PDT)
photothermal therapy (PPT)
silica
tumors
Article
Funding: This study was supported by grants No. 14-13-01167 (designing of nanoparticles, multifunctional gold-based nanocomposites, and fluorescent atomic nanoclusters) and No. 14-15-00186 (nanoparticle mediated laser cell/tissue interactions) from the Russian Scientific Foundation. BNK was supported by RFBR grant 15-33-20248.
Copyright information: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
  https://creativecommons.org/licenses/by/4.0/