University of Oulu

Myllylä, Teemu; Zacharias, Norman; Korhonen, Vesa; Zienkiewicz, Aleksandra; Hinrichs, Hermann; Kiviniemi, Vesa; Walter, Martin. Multimodal brain imaging with magnetoencephalography : a method for measuring blood pressure and cardiorespiratory oscillations. Scientific Reports 7, Article number: 172 (2017) doi:10.1038/s41598-017-00293-7

Multimodal brain imaging with magnetoencephalography : a method for measuring blood pressure and cardiorespiratory oscillations

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Author: Myllylä, Teemu1; Zacharias, Norman2,3; Korhonen, Vesa4,5;
Organizations: 1University of Oulu, Optoelectronics and Measurement Techniques Research Unit, Health & Wellness Measurements Group, Oulu, Finland
2Leibniz Institute for Neurobiology, Magdeburg, Germany
3Charité – Universitätsmedizin Berlin, Department of Anesthesiology, Neuroimaging Research Group, Berlin, Germany
4Oulu University Hospital, Department of Diagnostic Radiology, Oulu, Finland
5University of Oulu, Research Unit of Medical Imaging, Physics and Technology, Oulu Functional NeuroImaging Group, Oulu, Finland
6University Hospital Magdeburg, Clinic for Neurology, Magdeburg, Germany
7University of Tübingen, Department of Psychiatry, Tübingen, Germany
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 3.2 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe201705196648
Language: English
Published: Springer Nature, 2017
Publish Date: 2017-05-19
Description:

Abstract

Studies with magnetoencephalography (MEG) are still quite rarely combined simultaneously with methods that can provide a metabolic dimension to MEG investigations. In addition, continuous blood pressure measurements which comply with MEG compatibility requirements are lacking. For instance, by combining methods reflecting neurovascular status one could obtain more information on low frequency fluctuations that have recently gained increasing interest as a mediator of functional connectivity within brain networks. This paper presents a multimodal brain imaging setup, capable to non-invasively and continuously measure cerebral hemodynamic, cardiorespiratory and blood pressure oscillations simultaneously with MEG. In the setup, all methods apart from MEG rely on the use of fibre optics. In particular, we present a method for measuring of blood pressure and cardiorespiratory oscillations continuously with MEG. The potential of this type of multimodal setup for brain research is demonstrated by our preliminary studies on human, showing effects of mild hypercapnia, gathered simultaneously with the presented modalities.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 7
Article number: 172
DOI: 10.1038/s41598-017-00293-7
OADOI: https://oadoi.org/10.1038/s41598-017-00293-7
Type of Publication: A1 Journal article – refereed
Field of Science: 217 Medical engineering
Subjects:
Funding: TM and VKo are thankful for support from COST Action BM1205, partly related to this study. NZ received funding from the framework of the EU-funded FP7 research program: BioCog (Biomarker Development for Postoperative Cognitive Impairment in the Elderly): www.biocog.eu.
Copyright information: © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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