University of Oulu

Podlipská, J. et al. Structure-symptom relationship with wide-area ultrasound scanning of knee osteoarthritis. Sci. Rep. 7, 44470; doi: 10.1038/srep44470 (2017).

Structure-symptom relationship with wide-area ultrasound scanning of knee osteoarthritis

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Author: Podlipská, Jana1; Koski, Juhani M.2; Kaukinen, Päivi3,4;
Organizations: 1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland
2Department of Internal Medicine, Mikkeli Central Hospital, Mikkeli, Finland
3Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Kuopio, Finland
4Department of Physical and Rehabilitation Medicine, Kuopio University Hospital, Kuopio, Finland
5Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
6Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
7Center for Life Course Health Research, University of Oulu, Oulu, Finland
8Department of Physical and Rehabilitation Medicine, University of Helsinki, Finland
9Helsinki University Hospital, Helsinki, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
Persistent link:
Language: English
Published: Springer Nature, 2017
Publish Date: 2017-06-19


The aetiology of knee pain in osteoarthritis (OA) is heterogeneous and its relationship with structural changes and function is unclear. Our goal was to determine the prevalence of wide-area scanned ultrasound-defined knee OA structural features and their association with pain and functional impairment in 79 symptomatic and 63 asymptomatic subjects. All subjects underwent ultrasound knee wide-area scanning and the severity of articular cartilage degeneration, the presence and size of osteophytes, and meniscal extrusion were evaluated. Subjects filled in a self-administrated questionnaire on present knee pain, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) on clinical symptoms and function over the past week. Cartilage changes were the most prevalent followed by lateral meniscal extrusion, osteophytes and medial meniscal extrusion. The global femoral cartilage grade associated strongly with pain and the WOMAC index. Site-specifically, early medial cartilage changes and thinning in sulcus and lateral site were associated with symptoms. The presence of femoral lateral osteophytes was also associated with both outcomes. Using the novel wide-area ultrasound scanning technique, we were able to confirm the negative impact of femoral cartilage OA changes on clinical symptoms. Presence, not necessarily size, of lateral femoral osteophytes was also associated with increased pain and disability.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 7
Pages: 1 - 10
Article number: 44470
DOI: 10.1038/srep44470
Type of Publication: A1 Journal article – refereed
Field of Science: 217 Medical engineering
3126 Surgery, anesthesiology, intensive care, radiology
Funding: We would like to thank our research coordinator, Esa Liukkonen, Ph.D. for help with the selection and recruitment of the study subjects. We acknowledge the financial support of the University of Oulu (strategic funding), the Academy of Finland (grant 268378), the Radiological Society of Finland, and the International Doctoral Programme in Biomedical Engineering and Medical Physics (funded by the Ministry of Education and Culture and the Academy of Finland).
Academy of Finland Grant Number: 268378
Detailed Information: 268378 (Academy of Finland Funding decision)
Dataset Reference: Supplementary information:
Copyright information: © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit