University of Oulu

Javier Egea, Isabel Fabregat, Yves M. Frapart, Pietro Ghezzi, Agnes Görlach, Thomas Kietzmann, Kateryna Kubaichuk, Ulla G. Knaus, Manuela G. Lopez, Gloria Olaso-Gonzalez, Andreas Petry, Rainer Schulz, Jose Vina, Paul Winyard, Kahina Abbas, Opeyemi S. Ademowo, Catarina B. Afonso, Ioanna Andreadou, Haike Antelmann, Fernando Antunes, Mutay Aslan, Markus M. Bachschmid, Rui M. Barbosa, Vsevolod Belousov, Carsten Berndt, David Bernlohr, Esther Bertrán, Alberto Bindoli, Serge P. Bottari, Paula M. Brito, Guia Carrara, Ana I. Casas, Afroditi Chatzi, Niki Chondrogianni, Marcus Conrad, Marcus S. Cooke, João G. Costa, Antonio Cuadrado, Pham My-Chan Dang, Barbara De Smet, Bilge Debelec–Butuner, Irundika H.K. Dias, Joe Dan Dunn, Amanda J. Edson, Mariam El Assar, Jamel El-Benna, Péter Ferdinandy, Ana S. Fernandes, Kari E. Fladmark, Ulrich Förstermann, Rashid Giniatullin, Zoltán Giricz, Anikó Görbe, Helen Griffiths, Vaclav Hampl, Alina Hanf, Jan Herget, Pablo Hernansanz-Agustín, Melanie Hillion, Jingjing Huang, Serap Ilikay, Pidder Jansen-Dürr, Vincent Jaquet, Jaap A. Joles, Balaraman Kalyanaraman, Danylo Kaminskyy, Mahsa Karbaschi, Marina Kleanthous, Lars-Oliver Klotz, Bato Korac, Kemal Sami Korkmaz, Rafal Koziel, Damir Kračun, Karl-Heinz Krause, Vladimír Křen, Thomas Krieg, João Laranjinha, Antigone Lazou, Huige Li, Antonio Martínez-Ruiz, Reiko Matsui, Gethin J. McBean, Stuart P. Meredith, Joris Messens, Verónica Miguel, Yuliya Mikhed, Irina Milisav, Lidija Milković, Antonio Miranda-Vizuete, Miloš Mojović, María Monsalve, Pierre-Alexis Mouthuy, John Mulvey, Thomas Münzel, Vladimir Muzykantov, Isabel T.N. Nguyen, Matthias Oelze, Nuno G. Oliveira, Carlos M. Palmeira, Nikoletta Papaevgeniou, Aleksandra Pavićević, Brandán Pedre, Fabienne Peyrot, Marios Phylactides, Gratiela G. Pircalabioru, Andrew R. Pitt, Henrik E. Poulsen, Ignacio Prieto, Maria Pia Rigobello, Natalia Robledinos-Antón, Leocadio Rodríguez-Mañas, Anabela P. Rolo, Francis Rousset, Tatjana Ruskovska, Nuno Saraiva, Shlomo Sasson, Katrin Schröder, Khrystyna Semen, Tamara Seredenina, Anastasia Shakirzyanova, Geoffrey L. Smith, Thierry Soldati, Bebiana C. Sousa, Corinne M. Spickett, Ana Stancic, Marie José Stasia, Holger Steinbrenner, Višnja Stepanić, Sebastian Steven, Kostas Tokatlidis, Erkan Tuncay, Belma Turan, Fulvio Ursini, Jan Vacek, Olga Vajnerova, Kateřina Valentová, Frank Van Breusegem, Lokman Varisli, Elizabeth A. Veal, A. Suha Yalçın, Olha Yelisyeyeva, Neven Žarković, Martina Zatloukalová, Jacek Zielonka, Rhian M. Touyz, Andreas Papapetropoulos, Tilman Grune, Santiago Lamas, Harald H.H.W. Schmidt, Fabio Di Lisa, Andreas Daiber, European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS), Redox Biology, Volume 13, October 2017, Pages 94-162, ISSN 2213-2317, https://doi.org/10.1016/j.redox.2017.05.007.

European contribution to the study of ROS : a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

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Author: Egea, Javier1; Fabregat, Isabel2; Frapart, Yves M.3;
Ghezzi, Pietro4; Görlach, Agnes5; Kietzmann, Thomas6; Kubaichuk, Kateryna6; Knaus, Ulla G.7; Lopez, Manuela G.1; Olaso-Gonzalez, Gloria8; Petry, Andreas9; Schulz, Rainer10; Vina, Jose8; Winyard, Paul11; Abbas, Kahina3; Ademowo, Opeyemi S.12; Afonso, Catarina B.13; Andreadou, Ioanna14; Antelmann, Haike15; Antunes, Fernando16; Aslan, Mutay17; Bachschmid, Markus M.18; Barbosa, Rui M.19; Belousov, Vsevolod20; Berndt, Carsten21; Bernlohr, David22; Bertrán, Esther2; Bindoli, Alberto23; Bottari, Serge P.24; Brito, Paula M.25; Carrara, Guia26; Casas, Ana I.27; Chatzi, Afroditi28; Chondrogianni, Niki29; Conrad, Marcus30; Cooke, Marcus S.31; Costa, João G.32; Cuadrado, Antonio33; My-Chan Dang, Pham34; De Smet, Barbara35; Debelec-Butuner, Bilge36; Dias, Irundika H. K.12; Dunn, Joe D.an37; Edson, Amanda J.38; El Assar, Mariam39; El-Benna, Jamel34; Ferdinandy, Péter40; Fernandes, Ana S.41; Fladmark, Kari E.38; Förstermann, Ulrich42; Giniatullin, Rashid43; Giricz, Zoltán40; Görbe, Anikó40; Griffiths, Helen44; Hampl, Vaclav45; Hanf, Alina46; Herget, Jan45; Hernansanz-Agustín, Pablo47; Hillion, Melanie15; Huang, Jingjing48; Ilikay, Serap49; Jansen-Dürr, Pidder50; Jaquet, Vincent51; Joles, Jaap A.52; Kalyanaraman, Balaraman53; Kaminskyy, Danylo54; Karbaschi, Mahsa31; Kleanthous, Marina55; Klotz, Lars-Oliver56; Korac, Bato57; Korkmaz, Kemal S.ami58; Koziel, Rafal50; Kračun, Damir9; Krause, Karl-Heinz51; Křen, Vladimír59; Krieg, Thomas60; Laranjinha, João19; Lazou, Antigone61; Li, Huige42; Martínez-Ruiz, Antonio62; Matsui, Reiko18; McBean, Gethin J.63; Meredith, Stuart P.13; Messens, Joris64; Miguel, Verónica65; Mikhed, Yuliya46; Milisav, Irina66; Milković, Lidija67; Miranda-Vizuete, Antonio68; Mojović, Miloš69; Monsalve, María70; Mouthuy, Pierre-Alexis71; Mulvey, John60; Münzel, Thomas46; Muzykantov, Vladimir72; Nguyen, Isabel T. N.52; Oelze, Matthias46; Oliveira, Nuno G.73; Palmeira, Carlos M.74; Papaevgeniou, Nikoletta29; Pavićević, Aleksandra69; Pedre, Brandán64; Peyrot, Fabienne75; Phylactides, Marios55; Pircalabioru, Gratiela G.76; Pitt, Andrew R.13; Poulsen, Henrik E.77; Prieto, Ignacio70; Rigobello, Maria P.ia78; Robledinos-Antón, Natalia33; Rodríguez-Mañas, Leocadio79; Rolo, Anabela P.74; Rousset, Francis51; Ruskovska, Tatjana80; Saraiva, Nuno41; Sasson, Shlomo81; Schröder, Katrin82; Semen, Khrystyna54; Seredenina, Tamara51; Shakirzyanova, Anastasia43; Smith, Geoffrey L.26; Soldati, Thierry37; Sousa, Bebiana C.13; Spickett, Corinne M.12; Stancic, Ana57; Stasia, Marie J.osé83; Steinbrenner, Holger56; Stepanić, Višnja67; Steven, Sebastian46; Tokatlidis, Kostas28; Tuncay, Erkan84; Turan, Belma84; Ursini, Fulvio85; Vacek, Jan86; Vajnerova, Olga45; Valentová, Kateřina59; Van Breusegem, Frank87; Varisli, Lokman49; Veal, Elizabeth A.88; Yalçın, A S.uha89; Yelisyeyeva, Olha54; Žarković, Neven71; Zatloukalová, Martina86; Zielonka, Jacek53; Touyz, Rhian M.90; Papapetropoulos, Andreas91; Grune, Tilman92; Lamas, Santiago65; Schmidt, Harald H. H. W.27; Di Lisa, Fabio93; Daiber, Andreas94
Organizations: 1Institute Teofilo Hernando, Department of Pharmacology, School of Medicine. Univerisdad Autonoma de Madrid, Spain.
2Bellvitge Biomedical Research Institute (IDIBELL) and University of Barcelona (UB), L'Hospitalet, Barcelona, Spain.
3LCBPT, UMR 8601 CNRS - Paris Descartes University, Sorbonne Paris Cité, Paris, France.
4Brighton & Sussex Medical School, Brighton, UK.
5Experimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
6Faculty of Biochemistry and Molecular Medicine, and Biocenter Oulu, University of Oulu, Oulu, Finland.
7Conway Institute, School of Medicine, University College Dublin, Dublin, Ireland.
8Department of Physiology, University of Valencia, Spain.
9Experimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Munich, Germany.
10Institute of Physiology, JLU Giessen, Giessen, Germany.
11University of Exeter Medical School, St Luke's Campus, Exeter EX1 2LU, UK.
12Life & Health Sciences and Aston Research Centre for Healthy Ageing, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
13School of Life & Health Sciences, Aston University, Aston Triangle, Birmingham B47ET, UK.
14Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Greece.
15Institute for Biology-Microbiology, Freie Universität Berlin, Berlin, Germany.
16Departamento de Química e Bioquímica and Centro de Química e Bioquímica, Faculdade de Ciências, Portugal.
17Department of Medical Biochemistry, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
18Vascular Biology Section & Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
19Center for Neurosciences and Cell Biology, University of Coimbra and Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
20Molecular technologies laboratory, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow 117997, Russia.
21Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
22Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota - Twin Cities, USA.
23Institute of Neuroscience (CNR), Padova, Italy.
24GETI, Institute for Advanced Biosciences, INSERM U1029, CNRS UMR 5309, Grenoble-Alpes University and Radio-analysis Laboratory, CHU de Grenoble, Grenoble, France.
25Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal; Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal.
26Department of Pathology, University of Cambridge, Cambridge, UK.
27Department of Pharmacology & Personalized Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
28Institute of Molecular Cell and Systems Biology, College of Medical Veterinary and Life Sciences, University of Glasgow, University Avenue, Glasgow, UK.
29National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., 116 35 Athens, Greece.
30Helmholtz Center Munich, Institute of Developmental Genetics, Neuherberg, Germany.
31Oxidative Stress Group, Dept. Environmental & Occupational Health, Florida International University, Miami, FL 33199, USA.
32Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal; CBIOS, Universidade Lusófona Research Center for Biosciences & Health Technologies, Lisboa, Portugal.
33Instituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC, Instituto de Investigación Sanitaria La Paz (IdiPaz), Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
34Université Paris Diderot, Sorbonne Paris Cité, INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, Laboratoire d'Excellence Inflamex, Faculté de Médecine Xavier Bichat, Paris, France.
35Department of Plant Systems Biology, VIB, 9052 Ghent, Belgium; Structural Biology Research Center, VIB, 1050 Brussels, Belgium; Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Padova, Italy; Pharmahungary Group, Szeged, Hungary.
36Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Ege University, Bornova, Izmir 35100, Turkey.
37Department of Biochemistry, Science II, University of Geneva, 30 quai Ernest-Ansermet, 1211 Geneva-4, Switzerland.
38Department of Molecular Biology, University of Bergen, Bergen, Norway.
39Fundación para la Investigación Biomédica del Hospital Universitario de Getafe, Getafe, Spain.
40Department of Pharmacology and Pharmacotherapy, Medical Faculty, Semmelweis University, Budapest, Hungary; Pharmahungary Group, Szeged, Hungary.
41CBIOS, Universidade Lusófona Research Center for Biosciences & Health Technologies, Lisboa, Portugal.
42Department of Pharmacology, Johannes Gutenberg University Medical Center, Mainz, Germany.
43A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
44Life & Health Sciences and Aston Research Centre for Healthy Ageing, Aston University, Aston Triangle, Birmingham B4 7ET, UK; Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.
45Department of Physiology, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.
46Molecular Cardiology, Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.
47Servicio de Immunología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain; Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid (UAM) and Instituto de Investigaciones Biomédicas Alberto Sols, Madrid, Spain.
48Department of Plant Systems Biology, VIB, 9052 Ghent, Belgium; Structural Biology Research Center, VIB, 1050 Brussels, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium; Brussels Center for Redox Biology, Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
49Harran University, Arts and Science Faculty, Department of Biology, Cancer Biology Lab, Osmanbey Campus, Sanliurfa, Turkey.
50Institute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria.
51Dept. of Pathology and Immunology, Centre Médical Universitaire, Geneva, Switzerland.
52Department of Nephrology & Hypertension, University Medical Center Utrecht, The Netherlands.
53Medical College of Wisconsin, Milwaukee, USA.
54Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
55Molecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
56Institute of Nutrition, Department of Nutrigenomics, Friedrich Schiller University, Jena, Germany.
57University of Belgrade, Institute for Biological Research "Sinisa Stankovic" and Faculty of Biology, Belgrade, Serbia.
58Department of Bioengineering, Cancer Biology Laboratory, Faculty of Engineering, Ege University, Bornova, 35100 Izmir, Turkey.
59Institute of Microbiology, Laboratory of Biotransformation, Czech Academy of Sciences, Videnska 1083, CZ-142 20 Prague, Czech Republic.
60Department of Medicine, University of Cambridge, UK.
61School of Biology, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
62Servicio de Immunología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
63School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland.
64Structural Biology Research Center, VIB, 1050 Brussels, Belgium; Brussels Center for Redox Biology, Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
65Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Madrid, Spain.
66University of Ljubljana, Faculty of Medicine, Institute of Pathophysiology and Faculty of Health Sciences, Ljubljana, Slovenia.
67Ruđer Bošković Institute, Division of Molecular Medicine, Zagreb, Croatia.
68Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
69University of Belgrade, Faculty of Physical Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia.
70Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), Madrid, Spain.
71Laboratory for Oxidative Stress, Rudjer Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia.
72Department of Pharmacology, Center for Targeted Therapeutics & Translational Nanomedicine, ITMAT/CTSA Translational Research Center University of Pennsylvania The Perelman School of Medicine, Philadelphia, PA, USA.
73Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal.
74Center for Neurosciences & Cell Biology of the University of Coimbra, Coimbra, Portugal; Department of Life Sciences of the Faculty of Sciences & Technology of the University of Coimbra, Coimbra, Portugal.
75LCBPT, UMR 8601 CNRS - Paris Descartes University, Sorbonne Paris Cité, Paris, France; ESPE of Paris, Paris Sorbonne University, Paris, France.
76The Research Institute of University of Bucharest, Bucharest, Romania.
77Laboratory of Clinical Pharmacology, Rigshospitalet, University Hospital Copenhagen, Denmark; Department of Clinical Pharmacology, Bispebjerg Frederiksberg Hospital, University Hospital Copenhagen, Denmark; Department Q7642, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
78Department of Biomedical Sciences, University of Padova, via Ugo Bassi 58/b, 35131 Padova, Italy.
79Fundación para la Investigación Biomédica del Hospital Universitario de Getafe, Getafe, Spain; Servicio de Geriatría, Hospital Universitario de Getafe, Getafe, Spain.
80Faculty of Medical Sciences, Goce Delcev University, Stip, Republic of Macedonia.
81Institute for Drug Research, Section of Pharmacology, Diabetes Research Unit, The Hebrew University Faculty of Medicine, Jerusalem, Israel.
82Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany; DZHK (German Centre for Cardiovascular Research), partner site Rhine-Main, Mainz, Germany.
83Université Grenoble Alpes, CNRS, Grenoble INP, CHU Grenoble Alpes, TIMC-IMAG, F38000 Grenoble, France; CDiReC, Pôle Biologie, CHU de Grenoble, Grenoble, F-38043, France.
84Department of Biophysics, Ankara University, Faculty of Medicine, 06100 Ankara, Turkey.
85Department of Molecular Medicine, University of Padova, Padova, Italy.
86Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hnevotinska 3, Olomouc 77515, Czech Republic.
87Department of Plant Systems Biology, VIB, 9052 Ghent, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.
88Institute for Cell and Molecular Biosciences, and Institute for Ageing, Newcastle University, Framlington Place, Newcastle upon Tyne, UK.
89Department of Biochemistry, School of Medicine, Marmara University, İstanbul, Turkey.
90Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK.
91Laboratoty of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Greece.
92German Institute of Human Nutrition, Department of Toxicology, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
93Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Padova, Italy. Electronic address: dilisa@bio.unipd.it.
94Molecular Cardiology, Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany; DZHK (German Centre for Cardiovascular Research), partner site Rhine-Main, Mainz, Germany. Electronic address: daiber@uni-mainz.de.
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 4.9 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe201706287529
Language: English
Published: Elsevier, 2017
Publish Date: 2017-06-28
Description:

Abstract

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.
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Series: Redox biology
ISSN: 2213-2317
ISSN-E: 2213-2317
ISSN-L: 2213-2317
Volume: 13
Issue: October
Pages: 94 - 162
DOI: 10.1016/j.redox.2017.05.007
OADOI: https://oadoi.org/10.1016/j.redox.2017.05.007
Type of Publication: A2 Review article in a scientific journal
Field of Science: 1182 Biochemistry, cell and molecular biology
Subjects:
Funding: The EU-ROS consortium (COST Action BM1203) was supported by the European Cooperation in Science and Technology (COST). The present overview represents the final Action dissemination summariz ing the major achievements of COST Action BM1203 (EU-ROS) as well as research news and personal views of its members. Some authors were also supported by COST Actions BM1005 (ENOG) and BM1307 (PROTEOSTASIS), as well as funding from the European Commission FP7 and H2020 programmes, and several national funding agencies.
Copyright information: © 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
  https://creativecommons.org/licenses/by-nc-nd/4.0/