University of Oulu

Minna E. Kubin, Nina Kokkonen, Riitta Palatsi, Päivi M. Hägg, Juha P. Väyrynen, Virpi Glumoff, Kirsi-Maria Haapasaari, Tiina Hurskainen, Kaisa Tasanen. Clinical efficiency of topical calcipotriol/betamethasone treatment in psoriasis relies on suppression of the inflammatory TNFα – IL- 23 – IL-17 axis. Acta Derm Venereol 2017; 97: 449–455. doi: 10.2340/00015555-2579

Clinical efficiency of topical calcipotriol/betamethasone treatment in psoriasis relies on suppression of the inflammatory TNFα – IL- 23 – IL-17 axis

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Author: Kubin, Minna E.1; Kokkonen, Nina1; Palatsi, Riitta1;
Organizations: 11PEDEGO Research Unit, Oulu Center for Cell-Matrix Research, Department of Dermatology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu
2Cancer and Translational Medicine Research Unit, Department of Pathology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu
3Biomedicine, Medical Microbiology and Immunology Research Unit, University of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.1 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe201707047628
Language: English
Published: Society for Publication of Acta Dermato-Venereologica, 2017
Publish Date: 2017-07-04
Description:

Abstract

The effects of topical calcipotriol/betamethasone combination therapy and betamethasone monotherapy on inflammatory T-cell numbers and molecular markers were compared in patients with psoriasis. Combination therapy down-regulated the expression of tumour necrosis factor (TNF)-α, interleukin (IL)-23A, IL-17A, S100A7, CCL-20 and interferon (IFN)-γ in skin and TNF-α, IL-6, IL-23A, T-bet and IFN-γ in peripheral blood mononuclear cells (PBMCs). Betamethasone monotherapy had less effect. Expression of FoxP3 in both skin and PBMCs was down-regulated by calcipotriol/betamethasone, but not by betamethasone. Immunohistochemical analysis revealed that calcipotriol/betamethasone reduced the numbers of CD4+ and CD8+ T cells and Tregs in psoriatic lesions more than betamethasone. Flow cytometric analyses demonstrated that calcipotriol/betamethasone decreased the numbers of circulating CD8+ T cells, Tregs, skin-homing Th17 memory cells and Th22 memory cells, while betamethasone had little or no effect. Glucocorticoid receptors GRα and GRß were expressed in psoriatic skin. In conclusion, calcipotriol increases the immunosuppressive power of betamethasone by suppressing the inflammatory TNF-α – IL-23 – IL-17 axis.

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Series: Acta dermato-venereologica
ISSN: 0001-5555
ISSN-E: 1651-2057
ISSN-L: 0001-5555
Volume: 97
Issue: 4
Pages: 449 - 455
DOI: 10.2340/00015555-2579
OADOI: https://oadoi.org/10.2340/00015555-2579
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 Internal medicine
Subjects:
Funding: This work was supported by Medical Research Center Oulu Doctoral Program, Finnish Dermatological Society, Finnish Medical Foundation, Väinö and Laina Kivi Foundation.
Copyright information: Journal Compilation © 2017 Acta Dermato-Venereologica. This is an open access article under the CC BY-NC license.
  https://creativecommons.org/licenses/by-nc/4.0/