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Nolte, I., Munoz, M., Tragante, V., Amare, A., Jansen, R., Vaez, A., von der Heyde, B., Avery, C., Bis, J., Dierckx, B., van Dongen, J., Gogarten, S., Goyette, P., Hernesniemi, J., Huikari, V., Hwang, S., Jaju, D., Kerr, K., Kluttig, A., Krijthe, B., Kumar, J., van der Laan, S., Lyytikäinen, L., Maihofer, A., Minassian, A., van der Most, P., Müller-Nurasyid, M., Nivard, M., Salvi, E., Stewart, J., Thayer, J., Verweij, N., Wong, A., Zabaneh, D., Zafarmand, M., Abdellaoui, A., Albarwani, S., Albert, C., Alonso, A., Ashar, F., Auvinen, J., Axelsson, T., Baker, D., de Bakker, P., Barcella, M., Bayoumi, R., Bieringa, R., Boomsma, D., Boucher, G., Britton, A., Christophersen, I., Dietrich, A., Ehret, G., Ellinor, P., Eskola, M., Felix, J., Floras, J., Franco, O., Friberg, P., Gademan, M., Geyer, M., Giedraitis, V., Hartman, C., Hemerich, D., Hofman, A., Hottenga, J., Huikuri, H., Hutri-Kähönen, N., Jouven, X., Junttila, J., Juonala, M., Kiviniemi, A., Kors, J., Kumari, M., Kuznetsova, T., Laurie, C., Lefrandt, J., Li, Y., Li, Y., Liao, D., Limacher, M., Lin, H., Lindgren, C., Lubitz, S., Mahajan, A., McKnight, B., zu Schwabedissen, H., Milaneschi, Y., Mononen, N., Morris, A., Nalls, M., Navis, G., Neijts, M., Nikus, K., North, K., O’Connor, D., Ormel, J., Perz, S., Peters, A., Psaty, B., Raitakari, O., Risbrough, V., Sinner, M., Siscovick, D., Smit, J., Smith, N., Soliman, E., Sotoodehnia, N., Staessen, J., Stein, P., Stilp, A., Stolarz-Skrzypek, K., Strauch, K., Sundström, J., Swenne, C., Syvänen, A., Tardif, J., Taylor, K., Teumer, A., Thornton, T., Tinker, L., Uitterlinden, A., van Setten, J., Voss, A., Waldenberger, M., Wilhelmsen, K., Willemsen, G., Wong, Q., Zhang, Z., Zonderman, A., Cusi, D., Evans, M., Greiser, H., van der Harst, P., Hassan, M., Ingelsson, E., Järvelin, M., Kääb, S., Kähönen, M., Kivimaki, M., Kooperberg, C., Kuh, D., Lehtimäki, T., Lind, L., Nievergelt, C., O’Donnell, C., Oldehinkel, A., Penninx, B., Reiner, A., Riese, H., van Roon, A., Rioux, J., Rotter, J., Sofer, T., Stricker, B., Tiemeier, H., Vrijkotte, T., Asselbergs, F., Brundel, B., Heckbert, S., Whitsel, E., den Hoed, M., Snieder, H., de Geus, E. (2017) Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nature Communications, 8 (), 15805. doi:10.1038/ncomms15805

Genetic loci associated with heart rate variability and their effects on cardiac disease risk

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Author: Nolte, Ilja M.1; Munoz, M. Loretto1; Tragante, Vinicius2;
Amare, Azmeraw T.1,3,4; Jansen, Rick5; Vaez, Ahmad1,6; von der Heyde, Benedikt7,8; Avery, Christy L.9; Bis, Joshua C.10; Dierckx, Bram11,12; van Dongen, Jenny13; Gogarten, Stephanie M.14; Goyette, Philippe15; Hernesniemi, Jussi16,17,18; Huikari, Ville19; Hwang, Shih-Jen20,21; Jaju, Deepali22; Kerr, Kathleen F.14; Kluttig, Alexander23; Krijthe, Bouwe P.24; Kumar, Jitender7,8; van der Laan, Sander W.25; Lyytikäinen, Leo-Pekka16,17; Maihofer, Adam X.26,27; Minassian, Arpi26,27; van der Most, Peter J.1; Mueller-Nurasyid, Martina28,29,30; Nivard, Michel13,31,32; Salvi, Erika33; Stewart, James D.9,34; Thayer, Julian F.35; Verweij, Niek36; Wong, Andrew37; Zabaneh, Delilah38,39; Zafarmand, Mohammad H.40,41; Abdellaoui, Abdel13,31,32; Albarwani, Sulayma42; Albert, Christine43; Alonso, Alvaro44; Ashar, Foram45; Auvinen, Juha19,46; Axelsson, Tomas47; Baker, Dewleen G.26,27; de Bakker, Paul I. W.48,49; Barcella, Matteo33; Bayoumi, Riad50; Bieringa, Rob J.1; Boomsma, Dorret13,31,32; Boucher, Gabrielle15; Britton, Annie R.51; Christophersen, Ingrid E.52,53,54,55; Dietrich, Andrea56; Ehret, George B.57,58; Ellinor, Patrick T.53,54,59,52; Eskola, Markku18,60; Felix, Janine F.24; Floras, John S.61,62,63; Franco, Oscar H.24; Friberg, Peter64; Gademan, Maaike G. J.40; Geyer, Mark A.26; Giedraitis, Vilmantas65; Hartman, Catharina A.66; Hemerich, Daiane2,67; Hofman, Albert24; Hottenga, Jouke-Jan13,31,32; Huikuri, Heikki68,69; Hutri-Kähönen, Nina70,71; Jouven, Xavier72; Junttila, Juhani68,69; Juonala, Markus73,74; Kiviniemi, Antti M.68,69; Kors, Jan A.75; Kumari, Meena51,76; Kuznetsova, Tatiana77; Laurie, Cathy C.14; Lefrandt, Joop D.78; Li, Yong79; Li, Yun80,81,82; Liao, Duanping83; Limacher, Marian C.84; Lin, Henry J.85,86; Lindgren, Cecilia M.87,88; Lubitz, Steven A.53,54,59,52; Mahajan, Anubha88; McKnight, Barbara10,14,89; zu Schwabedissen, Henriette Meyer90; Milaneschi, Yuri5; Mononen, Nina16,17; Morris, Andrew P.88,91; Nalls, Mike A.92; Navis, Gerjan93; Neijts, Melanie13,31,32; Nikus, Kjell18,60; North, Kari E.9,94; O'Connor, Daniel T.95; Ormel, Johan66; Perz, Siegfried96; Peters, Annette30,96,97; Psaty, Bruce M.10,98,99; Raitakari, Olli T.100,101; Risbrough, Victoria B.26,27; Sinner, Moritz F.29,30; Siscovick, David102; Smit, Johannes H.5; Smith, Nicholas L.99,103,104; Soliman, Elsayed Z.105; Sotoodehnia, Nona106; Staessen, Jan A.77; Stein, Phyllis K.107; Stilp, Adrienne M.14; Stolarz-Skrzypek, Katarzyna108; Strauch, Konstantin28,109; Sundström, Johan110; Swenne, Cees A.111; Syvänen, Ann-Christine47; Tardif, Jean-Claude15,112; Taylor, Kent D.113; Teumer, Alexander114; Thornton, Timothy A.14; Tinker, Lesley E.89; Uitterlinden, Andre G.24,115,116; van Setten, Jessica2; Voss, Andreas117; Waldenberger, Melanie11,96,118; Wilhelmsen, Kirk C.119,120; Willemsen, Gonneke13,31,32; Wong, Quenna14; Zhang, Zhu-Ming105,121; Zonderman, Alan B.122; Cusi, Daniele123,124; Evans, Michele K.122; Greiser, Halina K.125; van der Harst, Pim36; Hassan, Mohammad42; Ingelsson, Erik7,8,126; Järvelin, Marjo-Riitta19,46,127,128; Kaab, Stefan29,30; Kähönen, Mika129,130; Kivimäki, Mika51; Kooperberg, Charles89; Kuh, Diana37; Lehtimäki, Terho16,17; Lind, Lars110; Nievergelt, Caroline M.26,27; O'Donnell, Chris J.20,21,131; Oldehinkel, Albertine J.66; Penninx, Brenda5; Reiner, Alexander P.89,103; Riese, Harriette66; van Roon, Arie M.78; Rioux, John D.15,112; Rotter, Jerome I.113; Sofer, Tamar14; Stricker, Bruno H.24,132; Tiemeier, Henning11,24; Vrijkotte, Tanja G. M.40; Asselbergs, Folkert W.2,133,134; Brundel, Bianca J. J. M.135; Heckbert, Susan R.10,103; Whitsel, Eric A.9,136; den Hoed, Marcel7,8; Snieder, Harold1; de Geus, Eco J. C.13,31,32
Organizations: 1Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, POB 30001, NL-9700 RB Groningen, Netherlands.
2Univ Med Ctr Utrecht, Div Heart & Lungs, Dept Cardiol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.
3Univ Adelaide, Sch Med, Dept Epidemiol, Adelaide, SA 5005, Australia.
4Bahir Dar Univ, Coll Med & Hlth Sci, Bahir Dar 6000, Ethiopia.
5Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res & Neurosci, Dept Psychiat,GGZ inGeest, Campus Amsterdam, NL-1081 BT Amsterdam, Netherlands.
6Isfahan Univ Med Sci, Sch Med, Esfahan 8174673461, Iran.
7Uppsala Univ, Dept Med Sci Mol Epidemiol, S-75237 Uppsala, Sweden.
8Uppsala Univ, Sci Life Lab, S-75237 Uppsala, Sweden.
9Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA.
10Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98104 USA.
11Dept Child & Adolescent Psychiat, Dept Child & Adolescent Psychiat Psychol, POB 2060, NL-3000 CB Rotterdam, Netherlands.
12Erasmus MC, Generat Study Grp R, POB 2060, NL-3000 CB0 Rotterdam, Netherlands.
13Vrije Univ Amsterdam, Dept Biol Psychol Behav & Movement Sci, NL-1081 BT Amsterdam, Netherlands.
14Univ Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98195 USA.
15Montreal Heart Inst, Montreal, PQ H1T IC8, Canada.
16Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland.
17Univ Tampere, Dept Clin Chem, Sch Med, Tampere 33014, Finland.
18Tampere Univ Hosp, Heart Hosp, Dept Cardiol, Tampere 33521, Finland.
19Univ Oulu, Ctr Life Course Hlth Res, Oulu 90014, Finland.
20Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA.
21NHLBI, Populat Sci Branch, NIH, Bethesda, MD 20892 USA.
22Sultan Qaboos Univ Hosp, Dept Clin Physiol, Muscat 123, Oman.
23Martin Luther Univ Halle Wittenberg, Inst Med Epidemiol Biostat & Informat, D-06097 Halle, Germany.
24Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, POB 2060, NL-3000 CB Rotterdam, Netherlands.
25Univ Med Ctr Utrecht, Dept Heart & Lung, Lab Expt Cardiol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.
26Univ Calif San Diego, Dept Psychiat, San Diego, CA 92093 USA.
27VA San Diego Healthcare Syst, Ctr Stress & Mental Hlth CESAMH, San Diego, CA 92161 USA.
28Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany.
29Ludwig Maximilians Univ Munchen, Dept Med, Univ Hosp Munich, D-80539 Munich, Germany.
30Munich Heart Alliance, DZHK German Ctr Cardiovasc Res, Partner Site, D-80336 Munich, Germany.
31Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, NL-1081 HV Amsterdam, Netherlands.
32Vrije Univ Amsterdam, Med Ctr, NL-1081 HV Amsterdam, Netherlands.
33Univ Milan, Dept Hlth Sci, I-20122 Milan, Italy.
34Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC 27599 USA.
35Ohio State Univ, Dept Psychol, 1835 Neil Ave, Columbus, OH 43210 USA.
36Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, POB 30001, NL-9700 RB Groningen, Netherlands.
37UCL, MRC Unit Lifelong Hlth & Ageing, 33 Bedford Pl, London WC1B 5JU, England.
38Kings Coll London, Inst Psychiat Psychol & Neurosci, De Crespigny Pk, London SE5 8AF, England.
39UCL, Genet Inst, London WC1E 6BT, England.
40Univ Amsterdam, Acad Med Ctr, Dept Publ Hlth, NL-1105 AZ Amsterdam, Netherlands.
41Univ Amsterdam, Acad Med Ctr, Dept Obstet & Gynaecol, NL-1105 AZ Amsterdam, Netherlands.
42Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Physiol, Muscat Al Khoudh 123, Oman.
43Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA.
44Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
45Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA.
46Oulu Univ Hosp, Unit Primary Hlth Care, Oulu 90220, Finland.
47Uppsala Univ, Dept Med Sci Mol Med, S-75237 Uppsala, Sweden.
48Univ Med Ctr Utrecht, Dept Genet, Ctr Mol Med, NL-3584 CX Utrecht, Netherlands.
49Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, NL-3584 CX Utrecht, Netherlands.
50Mohammed Bin Rashid Univ, Coll Med, Dubai Healthcare City, POB 505055, Dubai, U Arab Emirates.
51UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
52Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.
53Broad Inst Harvard, Program Med & Populat Genet, Cambridge, MA 02114 USA.
54MIT, Cambridge, MA 02114 USA.
55Baerum Hosp, Vestre Viken Hosp Trust, Dept Med Res, N-1346 Rud, Norway.
56Univ Groningen, Univ Med Ctr Groningen, Dept Child & Adolescent Psychiat, POB 30001, NL-9700 RB Groningen, Netherlands.
57Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Ctr Complex Dis Genom, Baltimore, MD 21205 USA.
58Geneva Univ Hosp, Dept Specialties Internal Med, Cardiol, CH-1211 Geneva, Switzerland.
59Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Boston, MA 02114 USA.
60Univ Tampere, Sch Med, Dept Cardiol, Tampere 33014, Finland.
61Univ Toronto, Univ Hlth Network, Toronto, ON, Canada.
62Univ Toronto, Mt Sinai Hosp, Div Cardiol, Dept Med, Toronto, ON, Canada.
63Univ Hlth Network, Toronto Gen Res Inst, Toronto, ON M5G 2C4, Canada.
64Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Med, Dept Mol & Clin Med, SE-41345 Gothenburg, Sweden.
65Uppsala Univ, Dept Publ Hlth & Caring Sci Mol Geriatr, S-75237 Uppsala, Sweden.
66Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Dept Psychiat, POB 30001, NL-9700 RB Groningen, Netherlands.
67Minist Educ Brazil, CAPES Fdn, BR-70040020 Brasilia, DF, Brazil.
68Oulu Univ Hosp, Med Res Ctr, Res Unit Internal Med, Oulu 90220, Finland.
69Univ Oulu, SF-90220 Oulu, Finland.
70Tampere Univ Hosp, Dept Pediat, Tampere 33521, Finland.
71Univ Tampere, Sch Med, Dept Pediat, Tampere 33014, Finland.
72Paris Descartes Univ, INSERM, U970, F-75006 Paris, France.
73Univ Turku, Dept Med, Turku 20520, Finland.
74Turku Univ Hosp, Div Med, Turku 20521, Finland.
75Erasmus MC, Dept Med Informat, NL-3015 CE Rotterdam, Netherlands.
76Essex Univ, ISER, Colchester CO4 3SQ, Essex, England.
77Univ Leuven, KU Leuven Dept Cardiovasc Sci, Studies Coordinating Ctr, Res Unit Hypertens & Cardiovasc Epidemiol, B-3000 Leuven, Belgium.
78Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Vasc Med, POB 30001, NL-9700 RB Groningen, Netherlands.
79Univ Freiburg, Fac Med, Med Center, Div Genet Epidemiol,Inst Med Biometry & Stat, D-79110 Freiburg, Germany.
80Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA.
81Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA.
82Univ N Carolina, Dept Comp Sci, Chapel Hill, NC 27599 USA.
83Penn State Univ, Coll Med, Dept Publ Hlth Sci, Div Epidemiol, Hershey, PA 17033 USA.
84Univ Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL 32611 USA.
85Harbor UCLA Med Ctr, Dept Pediat, Los Angeles Biomed Res Inst Harbor, Inst Translat Genom & Populat Sci, Torrance, CA 90502 USA.
86Harbor UCLA Med Ctr, Dept Pediat, Div Med Genet, Torrance, CA 90502 USA.
87Univ Oxford, Big Data Inst, Li Ka Shing Ctr Hlth Informat & Discovery, Oxford OX3 7BN, England.
88Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England.
89Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, Seattle, WA 98109 USA.
90Univ Basel, Dept Pharmaceut Sci, Biopharm, CH-4056 Basel, Switzerland.
91Univ Liverpool, Dept Biostat, Liverpool L69 3GL, Merseyside, England.
92NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA.
93Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Nephrol, POB 30001, NL-9700 RB Groningen, Netherlands.
94Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC 27599 USA.
95Univ Calif San Diego, Dept Med, San Diego, CA 92093 USA.
96Helmholtz Zentrum Munchen, Inst Epidemiol 2, German Res Ctr Environm Hlth, D-85764 Neuherberg, Germany.
97German Ctr Diabet Res, D-85764 Neuherberg, Germany.
98Univ Washington, Dept Epidemiol & Hlth Serv, Seattle, WA 98195 USA.
99Grp Hlth Cooperat Puget Sound, Grp Hlth Res Inst, Seattle, WA 98101 USA.
100Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku 20521, Finland.
101Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku 20520, Finland.
102New York Acad Med, New York, NY 10029 USA.
103Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.
104Vet Affairs Off Res & Dev, Seattle Epidemiol Res & Informat Ctr, Seattle, WA 98108 USA.
105Wake Forest Sch Med, Div Publ Hlth Sci, Epidemiol Cardiol Res Ctr EPICARE, Winston Salem, NC 27157 USA.
106Univ Washington, Dept Med & Epidemiol, Div Cardiol, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA.
107Washington Univ, Heart Rate Variabil Lab, Sch Med, St Louis, MO 63108 USA.
108Jagiellonian Univ, Med Coll, Dept Cardiol Intervent Electrocardi & Hypertens 1, PL-31008 Krakow, Poland.
109Ludwig Maximilians Univ Munchen, Chair Genet Epidemiol, Inst Med Informat Biometry & Epidemiol, D-81377 Munich, Germany.
110Uppsala Univ, Dept Med Sci Cardiovasc Epidemiol, S-75185 Uppsala, Sweden.
111Leiden Univ, Med Ctr, Dept Cardiol, NL-2300 RC Leiden, Netherlands.
112Univ Montreal, Montreal, PQ H3T IJ4, Canada.
113Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Dept Pediat & Med, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.
114Univ Med Greifswald, Inst Community Med, D-17475 Greifswald, Germany.
115Erasmus Univ, Med Ctr, Dept Internal Med, NL-3015 CE Rotterdam, Netherlands.
116Netherlands Consortium Hlth Aging, Netherlands Genom Initiat, NL-2300 RC Leiden, Netherlands.
117IGHT Jena Ernst Abbe Hsch, Inst Innovat Hlth Technol, D-07745 Jena, Germany.
118Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, D-85764 Neuherberg, Germany.
119Univ N Carolina, Dept Genet & Neurol, Chapel Hill, NC 27599 USA.
120Renaissance Comp Inst, Chapel Hill, NC 27599 USA.
121Wake Forest Sch Med, Div Publ Hlth Sci, Dept Epidemiol & Prevent, Winston Salem, NC 27157 USA.
122NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA.
123Italian Natl Res Council, CNR, Inst Biomed Technol, I-20090 Milan, Italy.
124KOS Genet SRL, I-20091 Milan, Italy.
125German Canc Res Ctr, Div Canc Epidemiol, D-69210 Heidelberg, Germany.
126Stanford Univ, Sch Med, Div Cardiovasc Med, Dept Med, Stanford, CA 94305 USA.
127Imperial Coll London, Fac Med, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus, London, England.
128Univ Oulu, Bioctr Oulu, Oulu 90014, Finland.
129Tampere Univ Hosp, Dept Clin Physiol, Tampere 33521, Finland.
130Univ Tampere, Sch Med, Dept Clin Physiol, Tampere 33014, Finland.
131Boston Vet Adm Healthcare Boston, Cardiol Sect, Boston, MD 02132 USA.
132Inspectorate Hlth Care, NL-2511 VX The Hague, Netherlands.
133UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England.
134ICIN Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, NL-3501 DG Utrecht, Netherlands.
135Vrije Univ Amsterdam, Inst Cardiovasc Res, Dept Physiol, Med Ctr, De Boelelaan 1118, NL-1081 HV Amsterdam, Netherlands.
136Univ N Carolina, Dept Med, Chapel Hill, NC 27599 USA.
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe201708178145
Language: English
Published: Springer Nature, 2017
Publish Date: 2017-08-30
Description:

Abstract

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74<rg<-0.55) and blood pressure (-0.35<rg<-0.20). These findings provide clinically relevant biological insight into heritable variation in vagal heart rhythm regulation, with a key role for genetic variants (GNG11, RGS6) that influence G-protein heterotrimer action in GIRK-channel induced pacemaker membrane hyperpolarization.

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Series: Nature communications
ISSN: 2041-1723
ISSN-E: 2041-1723
ISSN-L: 2041-1723
Issue: 8
Article number: 15805
DOI: 10.1038/ncomms15805
OADOI: https://oadoi.org/10.1038/ncomms15805
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Subjects:
Cardiovascular genetics
Genome-wide association studies
Risk factors
Article
Dataset Reference: Supplementary information
  https://images.nature.com/original/nature-assets/ncomms/2017/170614/ncomms15805/extref/ncomms15805-s2.xlsx
https://images.nature.com/original/nature-assets/ncomms/2017/170614/ncomms15805/extref/ncomms15805-s3.xlsx
https://images.nature.com/original/nature-assets/ncomms/2017/170614/ncomms15805/extref/ncomms15805-s4.xlsx
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