University of Oulu

Hanna-Riikka Teppo, Ylermi Soini, and Peeter Karihtala, “Reactive Oxygen Species-Mediated Mechanisms of Action of Targeted Cancer Therapy,” Oxidative Medicine and Cellular Longevity, vol. 2017, Article ID 1485283, 11 pages, 2017. doi:10.1155/2017/1485283

Reactive oxygen species-mediated mechanisms of action of targeted cancer therapy

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Author: Teppo, Hanna-Riikka1; Soini, Ylermi1; Karihtala, Peeter2
Organizations: 1Department of Pathology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
2Department of Oncology and Radiotherapy, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.5 MB)
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Language: English
Published: Hindawi, 2017
Publish Date: 2017-08-22


Targeted cancer therapies, involving tyrosine kinase inhibitors and monoclonal antibodies, for example, have recently led to substantial prolongation of survival in many metastatic cancers. Compared with traditional chemotherapy and radiotherapy, where reactive oxygen species (ROS) have been directly linked to the mediation of cytotoxic effects and adverse events, the field of oxidative stress regulation is still emerging in targeted cancer therapies. Here, we provide a comprehensive review regarding the current evidence of ROS-mediated effects of antibodies and tyrosine kinase inhibitors, use of which has been indicated in the treatment of solid malignancies and lymphomas. It can be concluded that there is rapidly emerging evidence of ROS-mediated effects of some of these compounds, which is also relevant in the context of drug resistance and how to overcome it.

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Series: Oxidative medicine and cellular longevity
ISSN: 1942-0900
ISSN-E: 1942-0994
ISSN-L: 1942-0900
Volume: 2017
Article number: 1485283
DOI: 10.1155/2017/1485283
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3122 Cancers
Copyright information: Copyright © 2017 Hanna-Riikka Teppo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.