Genome-wide physical activity interactions in adiposity : a meta-analysis of 200,452 adults |
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Author: | Graff, Mariaelisa1; Scott, Robert A.2; Justice, Anne E.1; |
Organizations: |
1Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. 2Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England. 3Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC USA.
4Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA.
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Format: | article |
Version: | published version |
Access: | open |
Online Access: | PDF Full Text (PDF, 1.5 MB) |
Persistent link: | http://urn.fi/urn:nbn:fi-fe201708228176 |
Language: | English |
Published: |
Public Library of Science,
2017
|
Publish Date: | 2017-08-22 |
Description: |
AbstractPhysical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery. see all
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Series: |
PLoS genetics |
ISSN: | 1553-7390 |
ISSN-E: | 1553-7404 |
ISSN-L: | 1553-7390 |
Volume: | 13 |
Issue: | 4 |
Article number: | e1006528 |
DOI: | 10.1371/journal.pgen.1006528 |
OADOI: | https://oadoi.org/10.1371/journal.pgen.1006528 |
Type of Publication: |
A1 Journal article – refereed |
Field of Science: |
3111 Biomedicine |
Subjects: | |
EU Grant Number: |
(277849) EURHEALTHAGEING - European ResearcH on DevElopmentAL, BirtH and Genetic Determinants of Ageing (279143) EPI-MIGRANT - Identification of epigenetic markers underlying increased risk of T2D in South Asians |
Dataset Reference: |
All genome-wide
association meta-analysis results files are available
at the GIANT Consortium website: www.
broadinstitute.org/collaboration/giant. |
www. broadinstitute.org/collaboration/giant |
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Copyright information: |
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. |
https://creativecommons.org/publicdomain/zero/1.0/ |