University of Oulu

Gao, P.; Wei, G.-H. Genomic Insight into the Role of lncRNAs in Cancer Susceptibility. Int. J. Mol. Sci. 2017, 18, 1239

Genomic insight into the role of lncRNAs in cancer susceptibility

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Author: Gao, Ping1,2; Wei, Gong-Hong1,2
Organizations: 1Biocenter Oulu
2Faculty of Biochemistry and Molecular Medicine, University of Oulu
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe201708238199
Language: English
Published: Multidisciplinary Digital Publishing Institute, 2017
Publish Date: 2017-08-23
Description:

Abstract

With the development of advanced genomic methods, a large amount of long non-coding RNAs (lncRNAs) have been found to be important for cancer initiation and progression. Given that most of the genome-wide association study (GWAS)-identified cancer risk SNPs are located in the noncoding region, the expression and function of lncRNAs are more likely to be affected by the SNPs. The SNPs may affect the expression of lncRNAs directly through disrupting the binding of transcription factors or indirectly by affecting the expression of regulatory factors. Moreover, SNPs may disrupt the interaction between lncRNAs and other RNAs orproteins. Unveiling the relationship of lncRNA, protein-coding genes, transcription factors and miRNAs from the angle of genomics will improve the accuracy of disease prediction and help find new therapeutic targets.

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Series: International journal of molecular sciences
ISSN: 1661-6596
ISSN-E: 1422-0067
ISSN-L: 1661-6596
Volume: 6
Issue: 18
Article number: 1239
DOI: 10.3390/ijms18061239
OADOI: https://oadoi.org/10.3390/ijms18061239
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
Subjects:
SNP
Copyright information: © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
  https://creativecommons.org/licenses/by/4.0/