University of Oulu

Papageorgiou SN, Antonoglou GN, Sándor GK, Eliades T (2017) Randomized clinical trials in orthodontics are rarely registered a priori and often published late or not at all. PLoS ONE 12(8): e0182785. https://doi.org/10.1371/journal.pone.0182785

Randomized clinical trials in orthodontics are rarely registered a priori and often published late or not at all

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Author: Papageorgiou, Spyridon N.1; Antonoglou, Georgios N.2,3; Sándor, George K.2,4;
Organizations: 1Clinic of Orthodontics and Pediatric Dentistry, Center of Dental Medicine, University of Zurich, Zurich, Switzerland
2Institute of Dentistry, Department of Oral and Maxillofacial Surgery, University of Oulu, Oulu, Finland
3Department of Periodontology and Implant Biology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece
4BioMediTech, Institute of Bioscience and Technology, University of Tampere, Tampere, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe201709188644
Language: English
Published: Public Library of Science, 2017
Publish Date: 2017-09-18
Description:

Abstract

A priori registration of randomized clinical trials is crucial to the transparency and credibility of their findings. Aim of this study was to assess the frequency with which registered and completed randomized trials in orthodontics are published. We searched ClinicalTrials.gov and ISRCTN for registered randomized clinical trials in orthodontics that had been completed up to January 2017 and judged the publication status and date of registered trials using a systematic protocol. Statistical analysis included descriptive statistics, chi-square or Fisher exact tests, and Kaplan-Meier survival estimates. From the 266 orthodontic trials registered up to January 2017, 80 trials had been completed and included in the present study. Among these 80 included trials, the majority (76%) were registered retrospectively, while only 33 (41%) were published at the time. The median time from completion to publication was 20.1 months (interquartile range: 9.1 to 31.6 months), while survival analysis indicated that less than 10% of the trials were published after 5 years from their completion. Finally, 22 (28%) of completed trials remain unpublished even after 5 years from their completion. Publication rates of registered randomized trials in orthodontics remained low, even 5 years after their completion date.

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Series: PLoS ONE
ISSN: 1932-6203
ISSN-E: 1932-6203
ISSN-L: 1932-6203
Volume: 12
Issue: 8
Article number: e0182785
DOI: 10.1371/journal.pone.0182785
OADOI: https://oadoi.org/10.1371/journal.pone.0182785
Type of Publication: A1 Journal article – refereed
Field of Science: 313 Dentistry
Subjects:
Copyright information: © 2017 Papageorgiou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
  https://creativecommons.org/licenses/by/4.0/