University of Oulu

Hänninen, N., Rautiainen, J., Rieppo, L., Saarakkala, S., Nissi, M. (2017) Orientation anisotropy of quantitative MRI relaxation parameters in ordered tissue. Scientific Reports, 7 (1), doi:10.1038/s41598-017-10053-2

Orientation anisotropy of quantitative MRI relaxation parameters in ordered tissue

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Author: Hänninen, Nina1,2; Rautiainen, Jari1; Rieppo, Lassi2,3;
Organizations: 1Department of Applied Physics, University of Eastern Finland
2Research Unit of Medical Imaging, Physics and Technology, University of Oulu
3Medical Research Center Oulu, Oulu University Hospital and University of Oulu
4Department of Diagnostic Radiology, Oulu University Hospital
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 3 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe201709258707
Language: English
Published: Nature Publishing Group, 2017
Publish Date: 2017-09-25
Description:

Abstract

In highly organized tissues, such as cartilage, tendons and white matter, several quantitative MRI parameters exhibit dependence on the orientation of the tissue constituents with respect to the main imaging magnetic field (B₀). In this study, we investigated the dependence of multiple relaxation parameters on the orientation of articular cartilage specimens in the B₀. Bovine patellar cartilage-bone samples (n = 4) were investigated ex vivo at 9.4 Tesla at seven different orientations, and the MRI results were compared with polarized light microscopy findings on specimen structure. Dependences of T₂ and continuous wave (CW)-T₁ᵨ relaxation times on cartilage orientation were confirmed. T₂ (and T₂*) had the highest sensitivity to orientation, followed by TRAFF2 and adiabatic T₂ᵨ. The highest dependence was seen in the highly organized deep cartilage and the smallest in the least organized transitional layer. Increasing spin-lock amplitude decreased the orientation dependence of CW-T. T₁ was found practically orientation-independent and was closely followed by adiabatic T₁ᵨ. The results suggest that T₁ and adiabatic T₁ᵨ should be preferred for orientation-independent quantitative assessment of organized tissues such as articular cartilage. On the other hand, based on the literature, parameters with higher orientation anisotropy appear to be more sensitive to degenerative changes in cartilage.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 7
Article number: 9606
DOI: 10.1038/s41598-017-10053-2
OADOI: https://oadoi.org/10.1038/s41598-017-10053-2
Type of Publication: A1 Journal article – refereed
Field of Science: 3126 Surgery, anesthesiology, intensive care, radiology
Subjects:
Funding: Financial support from the Academy of Finland (grants #285909, #293970, #297033, #268378 and #303786) and the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement no. 336267 are gratefully acknowledged.
Academy of Finland Grant Number: 285909
293970
297033
303786
Detailed Information: 285909 (Academy of Finland Funding decision)
293970 (Academy of Finland Funding decision)
297033 (Academy of Finland Funding decision)
303786 (Academy of Finland Funding decision)
Dataset Reference: Electronic supplementary material:
  https://static-content.springer.com/esm/art%3A10.1038%2Fs41598-017-10053-2/MediaObjects/41598_2017_10053_MOESM1_ESM.pdf
Copyright information: © The Authors. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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