University of Oulu

Chen, Y., Li, J., Hu, Y., Zhang, H., Yang, X., Jiang, Y., Yao, Z., Chen, Y., Gao, Y., Tan, A., Liao, M., Lu, Z., Wu, C., Xian, X., Wei, S., Zhang, Z., Chen, W., Wei, G., Wang, Q., Mo, Z. (2017) Multi-factors including Inflammatory/Immune, Hormones, Tumor-related Proteins and Nutrition associated with Chronic Prostatitis NIH IIIa+b and IV based on FAMHES project. Scientific Reports, 7 (1), doi:10.1038/s41598-017-09751-8

Multi-factors including inflammatory/immune, hormones, tumor-related proteins and nutrition associated with chronic prostatitis NIH IIIa+b and IV based on FAMHES project

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Author: Chen, Yang1,2,3,4,5; Li, Jie2,6; Hu, Yanling2,3,4,5;
Organizations: 1Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University
2Center for Genomic and Personalized Medicine, Guangxi Medical University
3Guangxi key laboratory for genomic and personalized medicine
4Guangxi collaborative innovation center for genomic and personalized medicine
5Guangxi key laboratory of colleges and universities
6The Guangxi Zhuang Autonomous Region Family Planning Research Center
7Biocenter Oulu, University of Oulu
8Faculty of Biochemistry and Molecular Medicine, University of Oulu
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2.7 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2017101050006
Language: English
Published: Nature Publishing Group, 2017
Publish Date: 2017-10-10
Description:

Abstract

Chronic prostatitis (CP) is a complex disease. Fragmentary evidence suggests that factors such as infection and autoimmunity might be associated with CP. To further elucidate potential risk factors, the current study utilized the Fangchenggang Area Male Health and Examination Survey (FAMHES) project; where 22 inflammatory/immune markers, hormone markers, tumor-related proteins, and nutrition-related variables were investigated. We also performed baseline, regression, discriminant, and receiver operating characteristic (ROC) analyses. According to NIH-Chronic Prostatitis Symptom Index (NIH-CPSI), participants were divided into chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS, pain ≥ 4; divided into IIIa and IIIb sub-groups) and non-CPPS (pain = 0; divided into IV and normal sub-groups). Analyses revealed osteocalcin as a consistent protective factor for CP/CPPS, NIH-IIIb, and NIH-IV prostatitis. Further discriminant analysis revealed that ferritin (p = 0.002) and prostate-specific antigen (PSA) (p = 0.010) were significantly associated with NIH-IIIa and NIH-IV prostatitis, respectively. Moreover, ROC analysis suggested that ferritin was the most valuable independent predictor of NIH-IIIa prostatitis (AUC = 0.639, 95% CI = 0.534–0.745, p = 0.006). Together, our study revealed inflammatory/immune markers [immunoglobulin E, Complement (C3, C4), C-reactive protein, anti-streptolysin, and rheumatoid factors], hormone markers (osteocalcin, testosterone, follicle-stimulating hormone, and insulin), tumor-related proteins (carcinoembryonic and PSA), and a nutrition-related variable (ferritin) were significantly associated with CP or one of its subtypes.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 7
Article number: 9143
DOI: 10.1038/s41598-017-09751-8
OADOI: https://oadoi.org/10.1038/s41598-017-09751-8
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
Subjects:
Funding: This study was funded by Guangxi Natural Science Fund for Innovation Research Team (2013GXNSFFA019002), Innovation Project of Guangxi Graduate Education (YCBZ2017037), Guangxi Collaborative Innovation Center for genomic and personalized medicine (201319), The Science and technology development plan of Guangxi (Guikegong 1355005-3-17), National Program on Key Basic Research Project (973 Program) (2012CB518303), Natural Science Foundation of China (81460388).
Copyright information: © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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