University of Oulu

Herzig, K., Leppäluoto, J., Jokelainen, J., Meugnier, E., Pesenti, S., Selänne, H., Mäkelä, K., Ahola, R., Jämsä, T., Vidal, H., Keinänen-Kiukaanniemi, S. (2017) Low level activity thresholds for changes in NMR biomarkers and genes in high risk subjects for Type 2 Diabetes. Scientific Reports, 7 (1), doi:10.1038/s41598-017-09753-6

Low level activity thresholds for changes in NMR biomarkers and genes in high risk subjects for type 2 diabetes

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Author: Herzig, Karl-Heinz1,2,3; Leppäluoto, Juhani1; Jokelainen, Jari4,5;
Organizations: 1Research Unit of Biomedicine, and Biocenter of Oulu, Oulu University
2Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences
3Medical Research Center and Oulu University Hospital, University of Oulu and Oulu University Hospital
4Center for Life Course Health Research, Faculty of Medicine, University of Oulu
5Oulu University Hospital, Unit of General Practice, and Health Center of Oulu
6CarMeN Laboratory, INSERM U1060, INRA U1397, University of Lyon
7Department of Education and Psychology, University of Jyväskylä
8Research Unit of Medical Imaging, Physics and Technology, University of Oulu
9Department of Diagnostic Imaging, Oulu University Hospital
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.9 MB)
Persistent link:
Language: English
Published: Springer Nature, 2017
Publish Date: 2017-11-09


Our objectives were to determine if there are quantitative associations between amounts and intensities of physical activities (PA) on NMR biomarkers and changes in skeletal muscle gene expressions in subjects with high risk for type 2 diabetes (T2D) performing a 3-month PA intervention. We found that PA was associated with beneficial biomarker changes in a factor containing several VLDL and HDL subclasses and lipids in principal component analysis (P = <0.01). Division of PA into quartiles demonstrated significant changes in NMR biomarkers in the 2nd – 4th quartiles compared to the 1st quartile representing PA of less than 2850 daily steps (P = 0.0036). Mediation analysis of PA-related reductions in lipoproteins showed that the effects of PA was 4–15 times greater than those of body weight or fat mass reductions. In a subset study in highly active subjects’ gene expressions of oxidative fiber markers, Apo D, and G0/G1 Switch Gene 2, controlling insulin signaling and glucose metabolism were significantly increased. Slow walking at speeds of 2–3 km/h exceeding 2895 steps/day attenuated several circulating lipoprotein lipids. The effects were mediated rather by PA than body weight or fat loss. Thus, lower thresholds for PA may exist for long term prevention of cardio-metabolic diseases in sedentary overweight subjects.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 7
Issue: 1
Article number: 11267
DOI: 10.1038/s41598-017-09753-6
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
3126 Surgery, anesthesiology, intensive care, radiology
Funding: The work was supported in part by the Finnish Diabetes Foundation (KHH) and EVO funds from Pohjois-Pohjanmaa Hospital District and Oulu University Hospital (SKK).
Dataset Reference: Supplementary information accompanies this paper at:
Copyright information: © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.