University of Oulu

Korppi, M., Teräsjärvi, J., Liehu-Martiskainen, M., Lauhkonen, E., Vuononvirta, J., Nuolivirta, K., Kröger, L., Pöyhönen, L., Karjalainen, M., He, Q. (2017) Haplotype of the Interleukin 17A gene is associated with osteitis after Bacillus Calmette-Guerin vaccination. Scientific Reports, 7 (1). doi:10.1038/s41598-017-12113-z

Haplotype of the Interleukin 17A gene is associated with osteitis after Bacillus Calmette-Guerin vaccination

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Author: Korppi, Matti1; Teräsjärvi, Johanna2; Liehu-Martiskainen, Milla1;
Organizations: 1Center for Child Health Research, University of Tampere and University Hospital, Tampere
2Department of Medical Microbiology and Immunology, University of Turku
3Department of Pediatrics, Seinäjoki Central Hospital
4Department of Pediatrics, Kuopio University Hospital
5St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University
6PEDEGO Research Unit and Medical Research Center Oulu, University of Oulu
7Department of Children and Adolescents, Oulu University Hospital
8Department of Medical Microbiology, Capital Medical University
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1 MB)
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Language: English
Published: Springer Nature, 2017
Publish Date: 2017-11-09


Bacillus Calmette-Guerin (BCG) osteitis was more common in Finland than elsewhere at the time when universal BCG vaccinations were given to Finnish newborns. There is evidence that IL-17 plays a role in the defense against tuberculosis. The aim of this study was to evaluate the associations of IL17A rs4711998, IL17A rs8193036 and IL17A rs2275913 single-nucleotide polymorphisms (SNPs) with the risk of BCG osteitis after newborn vaccination. IL17A rs4711998, rs8193036 and rs2275913 SNPs were determined in 131 adults had presented with BCG osteitis after newborn BCG vaccination. We analyzed, using the HaploView and PLINK programs, whether allele or haplotype frequencies of these SNPs differ between the former BCG osteitis patients and Finnish population controls. Of the three IL17A SNPs studied, rs4711998 associated nominally with BCG osteitis; minor allele frequency was 0.215 in 130 BCG osteitis cases and 0.298 in 99 controls (p = 0.034). Frequency of the second common haplotype (GTA) differed significantly between BCG osteitis cases and controls (0.296 vs. 0.184, p = 0.040 after multi-testing correction). The GTA haplotype of the IL17A SNPs rs4711998, rs8193036 and rs2275913 was associated with osteitis after BCG vaccination.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 7
Issue: 1
Article number: 11691
DOI: 10.1038/s41598-017-12113-z
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
3141 Health care science
Funding: Tampereen Tuberkuloosisäätiö (Tampere Tuberculosis Foundation supported the study by a grant to Johanna Teräsjärvi, Kirsi Nuolivirta and Laura Pöyhönen.
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