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Vitamin D and cognitive function : a Mendelian randomisation study |
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| Author: | Maddock, Jane1,2; Zhou, Ang3; Cavadino, Alana2,4; |
| Organizations: |
1MRC Lifelong Health and Ageing at UCL, London 2Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London 3Centre for Population Health Research, Sansom Institute, University of South Australia
4Wolfson Institute of Preventive Medicine, Queen Mary University of London
5University of Exeter Medical School 6Institute for Social and Economic Research (ISER), University of Essex 7Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ) 8Network Aging Research (NAR), University of Heidelberg 9Institute of Health Care and Social Sciences, FOM University 10Department of Epidemiology and Public Health, University College London 11Division of Internal Medicine, University Hospital of North Norway 12Endocrinology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway 13Center for Life Course Health Research, University of Oulu 14Oulu University Hospital 15Department of Medical Epidemiology and Biostatistics, Karolinska Institutet 16Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere 17Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku 18Department of Surgical Sciences, Uppsala University 19Department of Psychology and Logopedics, University of Helsinki 20Helsinki Collegium for Advanced Studies, University of Helsinki 21Department of Medicine, Internal Medicine, Lausanne University Hospital 22Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU) 23Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway 24Department of Cardiology, Akershus University Hospital 25INSERM, U1018, Centre for Research in Epidemiology and Population Health, Hôpital Paul Brousse 26Department of Pediatrics, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere 27Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere 28Department of Public Health and Caring Sciences, Uppsala University 29Department of Medical Sciences, Uppsala University 30Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine 31Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals 32Department of Epidemiology, Rollins School of Public Health, Emory University 33Department of Ambulatory Care and Community Medicine, University of Lausanne 34Division of General Neurology, Department of Neurology, General Hospital and Medical University of Graz 35Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz 36Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz 37Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, University of Helsinki 38Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital 39Research Unit of Biomedicine, University of Oulu 40Biocenter Oulu, University of Oulu 41Medical Research Center (MRC) and Oulu University Hospital 42Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences 43Department of Epidemiology and Biostatistics, MRC–PHE Centre for Environment & Health, School of Public Health, Imperial College London 44Research Unit of Clinical Neuroscience, Department of Psychiatry, University of Oulu 45Department of Psychiatry, University Hospital of Oulu 46Clinicum, University of Helsinki 47Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health 48South Australian Health and Medical Research Institute |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1.2 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2017112050795 |
| Language: | English |
| Published: |
Springer Nature,
2017
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| Publish Date: | 2017-11-20 |
| Description: |
AbstractThe causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25(OH)D tertiles, sex and age. Random effects meta-analyses assessed associations between 25(OH)D and cognitive function. Associations of serum 25(OH)D with global and memory-related cognitive function were non-linear (lower cognitive scores for both low and high 25(OH)D, pcurvature ≤ 0.006), with much of the curvature attributed to a single study. DHCR7, CYP2R1, and the synthesis score were associated with small reductions in 25(OH)D per vitamin D-decreasing allele. However, coefficients for associations with global or memory-related cognitive function were non-significant and in opposing directions for DHCR7 and CYP2R1, with no overall association observed for the synthesis score. Coefficients for the synthesis score and global and memory cognition were similar when stratified by 25(OH)D tertiles, sex and age. We found no evidence for serum 25(OH)D concentration as a causal factor for cognitive performance in mid- to later life. see all
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| Series: |
Scientific reports |
| ISSN: | 2045-2322 |
| ISSN-E: | 2045-2322 |
| ISSN-L: | 2045-2322 |
| Volume: | 7 |
| Issue: | 1 |
| Article number: | 13230 |
| DOI: | 10.1038/s41598-017-13189-3 |
| OADOI: | https://oadoi.org/10.1038/s41598-017-13189-3 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3142 Public health care science, environmental and occupational health 3112 Neurosciences |
| Subjects: | |
| Funding: |
Primary project funding came from The Judith Jane Mason & Harold Stannett Williams Memorial Foundation, other resources are listed in the supplementary material. |
| Dataset Reference: |
Supplementary material: |
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https://static-content.springer.com/esm/art%3A10.1038%2Fs41598-017-13189-3/MediaObjects/41598_2017_13189_MOESM1_ESM.pdf |
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| Copyright information: |
© The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
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https://creativecommons.org/licenses/by/4.0/ |