University of Oulu

Casula, V., Autio, J., Nissi, M. J., Auerbach, E. J., Ellermann, J., Lammentausta, E. and Nieminen, M. T. (2017), Validation and optimization of adiabatic T1ρ and T2ρ for quantitative imaging of articular cartilage at 3 T. Magn. Reson. Med., 77: 1265–1275. doi:10.1002/mrm.26183

Validation and optimization of adiabatic T1ρ and T2ρ for quantitative imaging of articular cartilage at 3 T

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Author: Casula, Victor1,2; Autio, Joonas3; Nissi, Mikko J.1,4,5,6;
Organizations: 1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland
2Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
3Center for Life Science and Technologies, RIKEN, Kobe, Japan
4Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN
5Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
6Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland
7Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 2 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2017121155593
Language: English
Published: John Wiley & Sons, 2017
Publish Date: 2017-12-11
Description:

Abstract

Purpose: The aim of the present work was to validate and optimize adiabatic T and T mapping for in vivo measurements of articular cartilage at 3 Tesla (T).

Methods: Phantom and in vivo experiments were systematically performed on a 3T clinical system to evaluate the sequences using hyperbolic secant HS1 and HS4 pulses. R and R relaxation rates were studied as a function of agarose and chondroitin sulfate concentration and pulse duration. Optimal in vivo protocol was determined by imaging the articular cartilage of two volunteers and varying the sequence parameters, and successively applied in eight additional subjects. Reproducibility was assessed in phantoms and in vivo.

Results: Relaxation rates depended on agarose and chondroitin sulfate concentration. The sequences were able to generate relaxation time maps with pulse lengths of 8 and 6 ms for HS1 and HS4, respectively. In vivo findings were in good agreement with the phantoms. The implemented adiabatic T and T sequences demonstrated regional variation in relaxation time maps of femorotibial cartilage. Reproducibility in phantoms and in vivo was good to excellent for both adiabatic T and T.

Conclusions: The findings indicate that sequences are suitable for quantitative in vivo assessment of articular cartilage at 3 T.

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Series: Magnetic resonance in medicine
ISSN: 0740-3194
ISSN-E: 1522-2594
ISSN-L: 0740-3194
Volume: 77
Issue: 3
Pages: 1265 - 1275
DOI: 10.1002/mrm.26183
OADOI: https://oadoi.org/10.1002/mrm.26183
Type of Publication: A1 Journal article – refereed
Field of Science: 114 Physical sciences
3126 Surgery, anesthesiology, intensive care, radiology
Subjects:
Funding: This work was supported by Academy of Finland (grants 260321, 285909, and 293970).
Academy of Finland Grant Number: 260321
Detailed Information: 260321 (Academy of Finland Funding decision)
Copyright information: © 2016 International Society for Magnetic Resonance in Medicine. This is the peer reviewed version of the following article: Casula, V., Autio, J., Nissi, M. J., Auerbach, E. J., Ellermann, J., Lammentausta, E. and Nieminen, M. T. (2017), Validation and optimization of adiabatic T1ρ and T2ρ for quantitative imaging of articular cartilage at 3 T. Magn. Reson. Med., 77: 1265–1275. doi:10.1002/mrm.26183, which has been published in final form at https://doi.org/10.1002/mrm.26183. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.