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Almangush, A., Pirinen, M., Heikkinen, I., Mäkitie, A., Salo, T., Leivo, I. (2017) Tumour budding in oral squamous cell carcinoma: a meta-analysis. British Journal of Cancer, 118, 577-586. doi:10.1038/bjc.2017.425

Tumour budding in oral squamous cell carcinoma : a meta-analysis

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Author: Almangush, Alhadi1,2,3; Pirinen, Matti4,5,6; Heikkinen, Ilkka1,2;
Organizations: 1Department of Pathology, University of Helsinki
2Department of Oral and Maxillofacial Diseases, University of Helsinki
3Institute of Dentistry, University of Misurata
4Institute for Molecular Medicine Finland (FIMM), University of Helsinki
5Helsinki Institute for Information Technology HIIT and Department of Mathematics and Statistics, University of Helsinki
6Department of Public Health, University of Helsinki
7Department of Otorhinolaryngology – Head and Neck Surgery, Helsinki University Hospital and University of Helsinki
8Helsinki University Hospital
9Research Group of Cancer Research and Translational Medicine, Medical Faculty, University of Oulu
10Medical Research Center, Oulu University Hospital
11Department of Pathology, University of Turku
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2017121555861
Language: English
Published: Springer Nature, 2017
Publish Date: 2018-11-30
Description:

Abstract

Background: Tumour budding has been reported as a promising prognostic marker in many cancers. This meta-analysis assessed the prognostic value of tumour budding in oral squamous cell carcinoma (OSCC).

Results: A total of 16 studies evaluated the prognostic value of tumour budding in OSCC. The meta-analysis showed that tumour budding was significantly associated with lymph node metastasis (odds ratio=7.08, 95% CI=1.75–28.73), disease-free survival (hazard ratio=1.83, 95% CI=1.34–2.50) and overall survival (hazard ratio=1.88, 95% CI=1.25–2.82).

Conclusions: Tumour budding is a simple and reliable prognostic marker for OSCC. Evaluation of tumour budding could facilitate personalised management of OSCC.

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Series: British journal of cancer
ISSN: 0007-0920
ISSN-E: 1532-1827
ISSN-L: 0007-0920
Volume: 118
Pages: 577 - 586
DOI: 10.1038/bjc.2017.425
OADOI: https://oadoi.org/10.1038/bjc.2017.425
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
Subjects:
invasive front
marker
oral squamous cell carcinoma
prognosis
survival
treatment
tumour budding
Article
Funding: This work was financially supported by the Finnish Dental Society (Alhadi Almangush), the Rauha Ahokas Foundation (Alhadi Almangush), the Academy of Finland (and 294050 to Matti Pirinen), the Research Funds of the University of Helsinki (Matti Pirinen), the Helsinki University Hospital Research Fund (Antti A Mäkitie and Tuula Salo), the Sigrid Juselius Foundation (Tuula Salo), the Finnish Cancer Society (Tuula Salo) and the Maritza and Reino Salonen Foundation (Ilmo Leivo).
Academy of Finland Grant Number: 288509
Detailed Information: 288509 (Academy of Finland Funding decision)
Copyright information: © 2017 Cancer Research UK. All rights reserved 0007 – 0920/17. This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License.
  https://creativecommons.org/licenses/by-nc-sa/4.0/