University of Oulu

Almangush, A., Leivo, I., Siponen, M. et al. Virchows Arch (2018) 472: 231. https://doi.org/10.1007/s00428-017-2212-1

Evaluation of the budding and depth of invasion (BD) model in oral tongue cancer biopsies

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Author: Almangush, Alhadi1,2,3; Leivo, Ilmo4; Siponen, Maria5,6,7;
Organizations: 1Department of Pathology, University of Helsinki, Helsinki, Finland
2Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland
3Institute of Dentistry, University of Misurata, Misurata, Libya
4Department of Pathology, University of Turku, Turku, Finland
5Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland
6Department of Oral and Maxillofacial Diseases, Kuopio University Hospital, Kuopio, Finland
7Institute of Dentistry, University of Eastern Finland, Kuopio, Finland
8Medical Research Center, Oulu University Hospital, Oulu, Finland
9Department of Otorhinolaryngology– Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
10Department of Pathology and Forensic Medicine, University of Eastern Finland, Kuopio and Cancer Center of Eastern Finland, Kuopio, Finland
11Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
12Research Programs Unit, Translational Cancer Biology, University of Helsinki, Helsinki, Finland
13Medical Informatics and Statistics Research Group, University of Oulu, Oulu, Finland
14HUSLAB, Department of Pathology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2017122156006
Language: English
Published: Springer Nature, 2018
Publish Date: 2018-08-02
Description:

Abstract

It is of great clinical importance to identify simple prognostic markers from preoperative biopsies that could guide treatment planning. Here, we compared tumor budding (B), depth of invasion (D), and the combined scores (i.e., budding and depth of invasion (BD) histopathologic model) in preoperative biopsies and the corresponding postoperative specimens of oral tongue squamous cell carcinoma (OTSCC). Tumor budding and depth of invasion were evaluated in the pre- and postoperative samples from 100 patients treated for OTSCC. Sensitivity and specificity statistics were used. Our results showed statistically significant (P < 0.001) relationship between pre- and postoperative BD scores. There was an agreement between the pre- and postoperative BD model scores in 83 cases (83%) with 57.1% sensitivity (95% CI 39.4 to 73.7%) and 96.9% specificity (95% CI 89.3 to 99.6%). Our findings suggest that the BD model, analyzed from representative biopsies, could be used for the treatment planning of OTSCC.

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Series: Virchows archiv. European journal of pathology
ISSN: 0945-6317
ISSN-E: 1432-2307
ISSN-L: 0945-6317
Volume: 472
Issue: 2
Pages: 231 - 236
DOI: 10.1007/s00428-017-2212-1
OADOI: https://oadoi.org/10.1007/s00428-017-2212-1
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
Subjects:
Funding: This study was supported by the Finnish Dental Society (Alhadi Almangush), the Maritza and Reino Salonen Foundation (Ilmo Leivo), and the Finnish Cancer Society (Tuula Salo).
Copyright information: © Springer-Verlag GmbH Deutschland 2017. This is a post-peer-review, pre-copyedit version of an article published in Virchows Archiv. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00428-017-2212-1