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Evaluation of the budding and depth of invasion (BD) model in oral tongue cancer biopsies |
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| Author: | Almangush, Alhadi1,2,3; Leivo, Ilmo4; Siponen, Maria5,6,7; |
| Organizations: |
1Department of Pathology, University of Helsinki, Helsinki, Finland 2Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland 3Institute of Dentistry, University of Misurata, Misurata, Libya
4Department of Pathology, University of Turku, Turku, Finland
5Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland 6Department of Oral and Maxillofacial Diseases, Kuopio University Hospital, Kuopio, Finland 7Institute of Dentistry, University of Eastern Finland, Kuopio, Finland 8Medical Research Center, Oulu University Hospital, Oulu, Finland 9Department of Otorhinolaryngology– Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland 10Department of Pathology and Forensic Medicine, University of Eastern Finland, Kuopio and Cancer Center of Eastern Finland, Kuopio, Finland 11Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 12Research Programs Unit, Translational Cancer Biology, University of Helsinki, Helsinki, Finland 13Medical Informatics and Statistics Research Group, University of Oulu, Oulu, Finland 14HUSLAB, Department of Pathology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland |
| Format: | article |
| Version: | accepted version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.6 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2017122156006 |
| Language: | English |
| Published: |
Springer Nature,
2018
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| Publish Date: | 2018-08-02 |
| Description: |
AbstractIt is of great clinical importance to identify simple prognostic markers from preoperative biopsies that could guide treatment planning. Here, we compared tumor budding (B), depth of invasion (D), and the combined scores (i.e., budding and depth of invasion (BD) histopathologic model) in preoperative biopsies and the corresponding postoperative specimens of oral tongue squamous cell carcinoma (OTSCC). Tumor budding and depth of invasion were evaluated in the pre- and postoperative samples from 100 patients treated for OTSCC. Sensitivity and specificity statistics were used. Our results showed statistically significant (P < 0.001) relationship between pre- and postoperative BD scores. There was an agreement between the pre- and postoperative BD model scores in 83 cases (83%) with 57.1% sensitivity (95% CI 39.4 to 73.7%) and 96.9% specificity (95% CI 89.3 to 99.6%). Our findings suggest that the BD model, analyzed from representative biopsies, could be used for the treatment planning of OTSCC. see all
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| Series: |
Virchows Archiv. European journal of pathology |
| ISSN: | 0945-6317 |
| ISSN-E: | 1432-2307 |
| ISSN-L: | 0945-6317 |
| Volume: | 472 |
| Issue: | 2 |
| Pages: | 231 - 236 |
| DOI: | 10.1007/s00428-017-2212-1 |
| OADOI: | https://oadoi.org/10.1007/s00428-017-2212-1 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3122 Cancers |
| Subjects: | |
| Funding: |
This study was supported by the Finnish Dental Society (Alhadi Almangush), the Maritza and Reino Salonen Foundation (Ilmo Leivo), and the Finnish Cancer Society (Tuula Salo). |
| Copyright information: |
© Springer-Verlag GmbH Deutschland 2017. This is a post-peer-review, pre-copyedit version of an article published in Virchows Archiv. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00428-017-2212-1 |