University of Oulu

Zhang, X., Wiklund, P., Wu, N., Yang, Y., Zhuang, H., Cheng, S. (2017) Association of leisure time physical activity and NMR-detected circulating amino acids in peripubertal girls: A 7.5-year longitudinal study. Scientific Reports, 7 (1). doi:10.1038/s41598-017-14116-2

Association of leisure time physical activity and NMR-detected circulating amino acids in peripubertal girls : a 7.5-year longitudinal study

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Author: Zhang, Xiaobo1; Wiklund, Petri2,3,4; Wu, Na1;
Organizations: 1School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
2Center for Life Course Health Research, University of Oulu
3Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
4Faculty of Sport and Health Sciences, University of Jyväskylä
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.3 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2017122256099
Language: English
Published: Springer Nature, 2017
Publish Date: 2017-12-22
Description:

Abstract

This study investigated the longitudinal associations of physical activity and circulating amino acids concentration in peripubertal girls. Three hundred ninety-six Finnish girls participated in the longitudinal study from childhood (mean age 11.2 years) to early adulthood (mean age 18.2 years). Circulating amino acids were assessed by nuclear magnetic resonance spectroscopy. LTPA was assessed by self-administered questionnaire. We found that isoleucine, leucine and tyrosine levels were significantly higher in individuals with lower LTPA than their peers at age 11 (p < 0.05 for all), independent of BMI. In addition, isoleucine and leucine levels increased significantly (~15%) from childhood to early adulthood among the individuals with consistently low LTPA (p < 0.05 for both), while among the individuals with consistently high LTPA the level of these amino acids remained virtually unchanged. In conclusion, high level of physical activity is associated lower serum isoleucine and leucine in peripubertal girls, independent of BMI, which may serve as a mechanistic link between high level of physical activity in childhood and its health benefits later in life. Further studies in peripubertal boys are needed to assess whether associations between physical activity and circulating amino acids in children adolescents are sex-specific.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 7
Article number: 14026
DOI: 10.1038/s41598-017-14116-2
OADOI: https://oadoi.org/10.1038/s41598-017-14116-2
Type of Publication: A1 Journal article – refereed
Field of Science: 315 Sport and fitness sciences
Subjects:
Funding: This work was supported financially by the Academy of Finland (Grant 24302031), the Ministry of Education of Finland, the University of Jyväskylä; the China State Sport General Administration (Grant 2015B039), and the National Nature Science Foundation of China (Grant 31571219), the Shanghai Jiao Tong University Zhiyuan Foundation (Grant CP2014013), and EVO research grants 2012/2013 from Oulu University Hospital.
Academy of Finland Grant Number: 24302031
Detailed Information: 24302031 (Academy of Finland Funding decision)
Copyright information: © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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