University of Oulu

Laura Di Sieno, Jan Nissinen, Lauri Hallman, Edoardo Martinenghi, Davide Contini, Antonio Pifferi, Juha Kostamovaara, Alberto D. Mora, "Miniaturized pulsed laser source for time-domain diffuse optics routes to wearable devices," Journal of Biomedical Optics 22(8), 085004 (19 August 2017). http://dx.doi.org/10.1117/1.JBO.22.8.085004

Miniaturized pulsed laser source for time-domain diffuse optics routes to wearable devices

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Author: Di Sieno, Laura1; Nissinen, Jan2; Hallman, Lauri2;
Organizations: 1Politecnico di Milano, Dipartimento di Fisica
2University of Oulu, Circuits and Systems Research Unit
3Consiglio Nazionale delle Ricerche, Istituto di Fotonica e Nanotecnologie
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 3.1 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe201801111231
Language: English
Published: International Society for Optical Engineering, 2017
Publish Date: 2018-01-11
Description:

Abstract

We validate a miniaturized pulsed laser source for use in time-domain (TD) diffuse optics, following rigorous and shared protocols for performance assessment of this class of devices. This compact source (12×6  mm2) has been previously developed for range finding applications and is able to provide short, high energy (∼100  ps, ∼0.5  nJ) optical pulses at up to 1 MHz repetition rate. Here, we start with a basic level laser characterization with an analysis of suitability of this laser for the diffuse optics application. Then, we present a TD optical system using this source and its performances in both recovering optical properties of tissue-mimicking homogeneous phantoms and in detecting localized absorption perturbations. Finally, as a proof of concept of in vivo application, we demonstrate that the system is able to detect hemodynamic changes occurring in the arm of healthy volunteers during a venous occlusion. Squeezing the laser source in a small footprint removes a key technological bottleneck that has hampered so far the realization of a miniaturized TD diffuse optics system, able to compete with already assessed continuous-wave devices in terms of size and cost, but with wider performance potentialities, as demonstrated by research over the last two decades.

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Series: Journal of biomedical optics
ISSN: 1083-3668
ISSN-E: 1560-2281
ISSN-L: 1083-3668
Volume: 22
Issue: 8
Article number: 085004
DOI: 10.1117/1.JBO.22.8.085004
OADOI: https://oadoi.org/10.1117/1.JBO.22.8.085004
Type of Publication: A1 Journal article – refereed
Field of Science: 213 Electronic, automation and communications engineering, electronics
217 Medical engineering
Subjects:
Funding: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 654148 Laserlab-Europe, the Academy of Finland (Centre of Excellence in Laser Scanning Research, contract nos. 272196, 255359, 283075, and 251571) and the Finnish Funding Agency for Innovation (TEKES).
Academy of Finland Grant Number: 272196
255359
283075
251571
Detailed Information: 272196 (Academy of Finland Funding decision)
255359 (Academy of Finland Funding decision)
283075 (Academy of Finland Funding decision)
251571 (Academy of Finland Funding decision)
Copyright information: © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
  https://creativecommons.org/licenses/by/3.0/