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Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease : a randomized controlled trial |
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| Author: | Cheng, Sulin1,2,3,; Ge, Jun4; Zhao, Can5; |
| Organizations: |
1Exercise, Health and Technology Centre, Department of Physical Education, Shanghai Jiao Tong University 2Faculty of Sport and Health Sciences, University of Jyväskylä 3The Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
4Shanghai Yangpu district Shidong Hospital
5School of Kinesiology, Shanghai University of Sport 6Clinical Nutrition Centre, Fudan University Huadong Hospital 7Bio-X, Shanghai Jiao Tong University 8Department of Diagnostic Radiology, University of Turku and Turku University Hospital 9Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen 10Department of Epidemiology and Biostatistics, Centre for Environment and Health, School of Public Health, Imperial College London 11Center for Life-Course Health Research, Faculty of Medicine, University of Oulu |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1.3 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe201802093260 |
| Language: | English |
| Published: |
Springer Nature,
2017
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| Publish Date: | 2018-02-09 |
| Description: |
AbstractThe study aimed to assess whether aerobic exercise (AEx) training and a fibre-enriched diet can reduce hepatic fat content (HFC) and increase glycaemic control in pre-diabetic patients with non-alcoholic fatty liver disease (NAFLD). Six-hundred-and-three patients from seven clinics in Yangpu district, Shanghai, China were recruited. Of them 115 individuals aged 50–65-year fulfilled the inclusion criteria (NAFLD with impaired fasting glucose or impaired glucose tolerance) and were randomly assigned into exercise (AEx n = 29), diet (Diet n = 28), exercise plus diet (AED n = 29), or no-intervention (NI n = 29) groups. Progressive supervised AEx training (60–75% VO2max intensity) was given 2–3 times/week in 30–60 min/sessions, and the diet intervention was provided as lunch with 38% carbohydrate and diet fibre of 12 g/day for 8.6-month. HFC was assessed by 1H MRS. We found that HFC was significantly reduced in the AEx (−24.4%), diet (−23.2%), and AED (−47.9%) groups by contrast to the 20.9% increase in the NI group (p = 0.001 for all) after intervention. However, only AED group significantly decreased HbA1c (−4.4%, p = 0.01) compared with the NI group (−0.6%). Aerobic exercise training combined with fibre-enriched diet can reduce HFC more effectively than either exercise or increased fibre-intake alone in pre-diabetic patients with NAFLD. see all
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| Series: |
Scientific reports |
| ISSN: | 2045-2322 |
| ISSN-E: | 2045-2322 |
| ISSN-L: | 2045-2322 |
| Volume: | 7 |
| Article number: | 15952 |
| DOI: | 10.1038/s41598-017-16159-x |
| OADOI: | https://oadoi.org/10.1038/s41598-017-16159-x |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3121 General medicine, internal medicine and other clinical medicine |
| Subjects: | |
| Funding: |
Funding for this study was provided by the China State Sport General Administration (2013B040, 2015B039), the Chinese Nature Science Foundation (NSFC 31571219), and the Shanghai Jiao Tong University Zhiyuan Foundation (CP2014013). Funding to RB was provided by the Sigrid Juselius Foundation, the Instrumentation Research Foundation, the Finnish Medical Foundation, the Paulo Foundation and the Academy of Finland (130557, 270352). |
| Academy of Finland Grant Number: |
130557 |
| Detailed Information: |
130557 (Academy of Finland Funding decision) |
| Copyright information: |
© The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
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https://creativecommons.org/licenses/by/4.0/ |