University of Oulu

Sironen, T., Sane, J., Lokki, M., Meri, S., Andersson, L., Hautala, T., Kauma, H., Vuorinen, S., Rasmuson, J., Evander, M., Ahlm, C., Vaheri, A. (2017) Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology. Open Forum Infectious Diseases, 4 (4), ofx229. doi:10.1093/ofid/ofx229

Fatal Puumala hantavirus disease : involvement of complement activation and vascular leakage in the pathobiology

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Author: Sironen, Tarja1; Sane, Jussi1; Lokki, Marja-Liisa1;
Organizations: 1Medicum, University of Helsinki
2Department of Internal Medicine, Oulu University Hospital
3Etelä-Savo Hospital District
4Department of Clinical Microbiology, Infectious Diseases, Umeå University
5Department of Clinical Microbiology, Virology, Umeå University
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.4 MB)
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Language: English
Published: Oxford University Press, 2017
Publish Date: 2018-02-09


The case-fatality rate of hantavirus disease depends strongly on the causative hantavirus, ranging from 0.1% to 40%. However, the pathogenesis is not fully understood, and at present no licensed therapies exist. We describe fatal cases caused by Puumala hantavirus indicating involvement of complement activation and vascular leakage.

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Series: Open forum infectious diseases
ISSN: 2328-8957
ISSN-E: 2328-8957
ISSN-L: 2328-8957
Volume: 4
Issue: 4
Article number: ofx229
DOI: 10.1093/ofid/ofx229
Type of Publication: A1 Journal article – refereed
Field of Science: 3141 Health care science
Funding: This work was supported by Sigrid Jusélius Foundation, Finland, The Swedish Foundation for Strategic Research, and Magnus Ehnrooth foundation.
Copyright information: © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (, which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact