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Preoperative anemia in colorectal cancer : relationships with tumor characteristics, systemic inflammation, and survival |
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| Author: | Väyrynen, Juha P.1,2; Tuomisto, Anne1,2; Väyrynen, Sara A.1,2; |
| Organizations: |
1Cancer and Translational Medicine Research Unit, University of Oulu 2Department of Pathology, Oulu University Hospital and Medical Research Center Oulu 3Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu
4Department of Surgery, Oulu University Hospital and Medical Research Center Oulu
5Research Unit of Biomedicine and Biocenter of Oulu, University of Oulu 6Oulu University Hospital and Medical Research Center Oulu 7Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1.3 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe201804096392 |
| Language: | English |
| Published: |
Springer Nature,
2018
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| Publish Date: | 2018-04-09 |
| Description: |
AbstractAnemia is common in colorectal cancer (CRC) but its relationships with tumor characteristics, systemic inflammation, and survival have not been well characterized. In this study, blood hemoglobin levels and erythrocyte mean corpuscular volume (MCV) levels were measured in two independent cohorts of 148 CRC patients and 208 CRC patients, and their correlation with patient and tumor characteristics, systemic inflammatory markers (modified Glasgow Prognostic Score: mGPS; serum levels of thirteen cytokines, C-reactive protein, albumin), and survival were analyzed. We found that anemia, most frequently normocytic, followed by microcytic, was present in 43% of the patients. Microcytic anemia was most commonly associated with proximal colon tumor location. Average MCV and blood hemoglobin levels were lower in tumors with high T-class. Low blood hemoglobin associated with systemic inflammation, including high mGPS and high serum levels of C-reactive protein and IL-8. Particularly, normocytic anemia associated with higher mGPS. Normocytic anemia associated with a tendency towards worse overall survival (multivariate hazard ratio 1.61, 95% confidence interval 1.07–2.42, p = 0.023; borderline statistical significance considering multiple hypothesis testing). In conclusion, anemia in CRC patients is most frequently normocytic. Proximal tumor location is associated with predominantly microcytic anemia and systemic inflammation is associated with normocytic anemia. see all
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| Series: |
Scientific reports |
| ISSN: | 2045-2322 |
| ISSN-E: | 2045-2322 |
| ISSN-L: | 2045-2322 |
| Volume: | 8 |
| Article number: | 1126 |
| DOI: | 10.1038/s41598-018-19572-y |
| OADOI: | https://oadoi.org/10.1038/s41598-018-19572-y |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3122 Cancers |
| Subjects: | |
| Copyright information: |
© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
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https://creativecommons.org/licenses/by/4.0/ |