University of Oulu

Suvi-Päivikki Sinikumpu, Laura Huilaja, Juha Auvinen, Jari Jokelainen, Katri Puukka, Aimo Ruokonen, Markku Timonen, Kaisa Tasanen The Association Between Low Grade Systemic Inflammation and Skin Diseases: A Cross-sectional Survey in the Northern Finland Birth Cohort 1966. Acta Derm Venereol 2018; 98:1, p.65-69. DOI: 10.2340/00015555-2795

The association between low grade systemic inflammation and skin diseases : a cross-sectional survey in the Northern Finland Birth Cohort 1966

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Author: Sinikumpu, Suvi-Päivikki1; Huilaja, Laura1; Auvinen, Juha2;
Organizations: 1Department of Dermatology and Medical Research Center Oulu, PEDEGO Research Unit, University of Oulu, Oulu University Hospital Oulu
2Center for Life Course Health Research, Faculty of Medicine, University of Oulu and Oulu University Hospital
3NordLab Oulu, Medical Research Center Oulu, Oulu University Hospital and Department of Clinical Chemistry, University of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
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Language: English
Published: Society for Publication of Acta Dermato-Venereologica, 2018
Publish Date: 2018-04-12


Low grade inflammation is associated with many noncommunicable diseases. The association between skin diseases in general and systemic inflammation has not previously been studied at the population level. A whole-body investigation on 1,930 adults belonging to Northern Finland Birth Cohort 1966 was performed and high sensitive C-reactive protein (CRP) level was measured as a marker of low grade inflammation in order to determine the association between low grade inflammation and skin diseases in an unselected adult population. After adjustment for confounding factors the following skin disorders were associated with low grade inflammation in multinomial logistic regression analysis: atopic eczema (OR 2.2, 95% CI 1.2–3.9), onychomycosis (OR 2.0, 1.2–3.2) and rosacea (OR 1.7, 1.1–2.5). After additionally adjusting for body mass index and systemic diseases, the risks for atopic eczema (OR 2.4, 1.3–4.6) and onychomycosis (OR 1.9, 1.1–3.1) remained statistically significant. In conclusion, low grade inflammation is present in several skin diseases.

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Series: Acta dermato-venereologica
ISSN: 0001-5555
ISSN-E: 1651-2057
ISSN-L: 0001-5555
Volume: 98
Issue: 1
Pages: 65 - 69
DOI: 10.2340/00015555-2795
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Funding: The study was supported by the Oulu University Hospital, the Northern Finland Cancer Association, the Academy of Finland, the Finnish Medical Foundation, the Medical Research Center Oulu, the Finnish Dermatological Society, the University of Oulu and the ERDF European Regional Development Fund – Well-being and health: Research in the Northern Finland Birth Cohort 1966 (grant no. 539/2010 A31592, 01.01.2011–31.12.2013).
Copyright information: © 2018 Acta Dermato-Venereologica. This is an open access article under the CC BY-NC license.