University of Oulu

Maurizi, G., Petäistö, T., Maurizi, A., Della Guardia, L. (2017) Key-genes regulating the liposecretion process of mature adipocytes. Journal of Cellular Physiology, 233 (5), 3784-3793. doi:10.1002/jcp.26188

Key‐genes regulating the liposecretion process of mature adipocytes

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Author: Maurizi, Giulia1; Petäistö, Tiina2; Maurizi, Angela3;
Organizations: 1Università Politecnica delle Marche
2Center for Cell‐Matrix Research, Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu
3Chirurgia Generale, ASUR Regione Marche, Ospedale “Carlo Urbani”
4Dipartimento di Sanità Pubblica, Medicina Sperimentale e Forense, Unità di Scienza dell'Alimentazione, Università degli stui di Pavia
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2018042418448
Language: English
Published: John Wiley & Sons, 2017
Publish Date: 2018-09-19
Description:

Abstract

White mature adipocytes (MAs) are plastic cells able to reversibly transdifferentiate toward fibroblast‐like cells maintaining stem cell gene signatures. The main morphologic aspect of this transdifferentiation process, called liposecretion, is the secretion of large lipid droplets and the development of organelles necessary for exocrine secretion. There is a considerable interest in the adipocyte plastic properties involving liposecretion process, but the molecular details are incompletely explored. This review analyzes the gene expression of MAs isolated from human subcutaneous fat tissue with respect to bone marrow (BM)‐derived mesenchymal stem cells (MSC) focusing on gene regulatory pathways involved into cellular morphology changes, cellular proliferation and transports of molecules through the membrane, suggesting potential ways to guide liposecretion. In particular, Wnt, MAPK/ERK, and AKT pathways were accurately described, studying up‐ and down‐stream molecules involved. Moreover, adipogenic extra‐ and intra‐cellular interactions were analyzed studying the role of CDH2, CDH11, ITGA5, E‐Syt1, PAI‐1, IGF1, and INHBB genes. Additionally, PLIN1 and PLIN2 could be key‐genes of liposecretion process regulating molecules transport through the membrane. All together data demonstrated that liposecretion is regulated through a complex molecular networks that are able to respond to microenvironment signals, cytokines, and growth factors. Autocrine as well as external signaling molecules might activate liposecretion affecting adipocytes physiology.

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Series: Journal of cellular physiology
ISSN: 0021-9541
ISSN-E: 1097-4652
ISSN-L: 0021-9541
Volume: 233
Issue: 5
Pages: 3784 - 3793
DOI: 10.1002/jcp.26188
OADOI: https://oadoi.org/10.1002/jcp.26188
Type of Publication: A2 Review article in a scientific journal
Field of Science: 1182 Biochemistry, cell and molecular biology
Subjects:
Copyright information: © 2017 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Maurizi, G., Petäistö, T., Maurizi, A., Della Guardia, L. (2017) Key-genes regulating the liposecretion process of mature adipocytes. Journal of Cellular Physiology, 233 (5), 3784-3793. doi:10.1002/jcp.26188, which has been published in final form at https://doi.org/10.1002/jcp.26188. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.