University of Oulu

A.W. Kajabi, V. Casula, M.J. Nissi, A. Peuna, J. Podlipská, E. Lammentausta, S. Saarakkala, A. Guermazi, M.T. Nieminen, Assessment of meniscus with adiabatic T1ρ and T2ρ relaxation time in asymptomatic subjects and patients with mild osteoarthritis: a feasibility study, Osteoarthritis and Cartilage, Volume 26, Issue 4, 2018, Pages 580-587, ISSN 1063-4584, https://doi.org/10.1016/j.joca.2017.12.006

Assessment of meniscus with adiabatic T1ρ and T2ρ relaxation time in asymptomatic subjects and patients with mild osteoarthritis : a feasibility study

Saved in:
Author: Kajabi, A.W.1,2; Casula, V.1,2; Nissi, M.J.3;
Organizations: 1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland
2Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
3Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
4Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
5Infotech Oulu, University of Oulu, Oulu, Finland
6Department of Radiology, Boston University School of Medicine, Boston, MA, USA
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2018042518500
Language: English
Published: Elsevier, 2018
Publish Date: 2018-04-25
Description:

Abstract

Objective: To investigate the ability of magnetic resonance imaging (MRI) adiabatic relaxation times in the rotating frame (adiabatic T and T) to detect structural alterations in meniscus tissue of mild OA patients and asymptomatic volunteers.

Method: MR images of 24 subjects (age range: 50–67 years, 12 male), including 12 patients with mild osteoarthritis (OA) (Kellgren–Lawrence (KL) = 1, 2) and 12 asymptomatic volunteers, were acquired using a 3 T clinical MRI system. Morphological assessment was performed using semiquantitative MRI OA Knee Score (MOAKS). Adiabatic T and T (AdT, AdT) relaxation time maps were calculated in regions of interest (ROIs) containing medial and lateral horns of menisci. The median relaxation time values of the ROIs were compared between subjects classified based on radiographic findings and MOAKS evaluations.

Results: MOAKS assessment of patients and volunteers indicated the presence of meniscal and cartilage lesions in both groups. For the combined cohort group, prolonged AdT was observed in the posterior horn of the medial meniscus (PHMED) in subjects with MOAKS meniscal tear (P < 0.05). AdT was statistically significantly longer in PHMED of subjects with MOAKS full-thickness cartilage loss (P < 0.05). After adjusting for multiple comparisons, differences in medians of observed AdT and AdT values between mild OA patients and asymptomatic volunteers did not reach statistical significance.

Conclusions: AdT and AdT measurements have the potential to identify changes in structural composition of meniscus tissue associated with meniscal tear and cartilage loss in a cohort group of mild OA patients and asymptomatic volunteers.

see all

Series: Osteoarthritis and cartilage
ISSN: 1063-4584
ISSN-E: 1522-9653
ISSN-L: 1063-4584
Volume: 26
Issue: 4
Pages: 580 - 587
DOI: 10.1016/j.joca.2017.12.006
OADOI: https://oadoi.org/10.1016/j.joca.2017.12.006
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
Subjects:
Funding: Our study was supported by the Academy of Finland (grants No 297033, 285909 and 293970), and Jane and Aatos Erkko Foundation
Academy of Finland Grant Number: 297033
Detailed Information: 297033 (Academy of Finland Funding decision)
Copyright information: © 2017 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an open access article under the CC BY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  https://creativecommons.org/licenses/by-nc-nd/4.0/