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Prognosis of schizophrenia spectrum disorder may not be predetermined during early development : the Northern Finland Birth Cohort 1966 |
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| Author: | Rautio, Nina1,2; Käkelä, Juha1,3,4; Nordström, Tanja1,4; |
| Organizations: |
1Center for Life Course Health Research, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland 2Unit of Primary Health Care, Oulu University Hospital, P.O. Box 20, 90029 OYS Oulu, Finland 3Research Unit of Clinical Neuroscience, Department of Psychiatry, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland
4Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, 90014 Oulu, Finland
5Department of Psychiatry, Oulu University Hospital, P.O. Box 20, 90029 OYS Oulu, Finland |
| Format: | article |
| Version: | accepted version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.6 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2018050219299 |
| Language: | English |
| Published: |
Elsevier,
2016
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| Publish Date: | 2017-03-09 |
| Description: |
AbstractBackground: Little is known about whether factors during the first years of life predict later outcomes in schizophrenia spectrum disorder (SSD). As part of the Northern Finland Birth Cohort 1966, we examined if prospectively collected early parenthood-related and developmental factors predict employment and hospitalization in individuals with and without SSD. Methods: Overall, 161 individuals with SSD and 10,116 without SSD were included in the study. Outcomes were analysed at age of 44–45 years, defining “employment” as being employed for at least 25% of working days and “hospitalization” as having psychiatric hospitalization at least once during the last two years of follow-up. Maternal age, wantedness of pregnancy, grand multiparity, parental psychoses, birth weight, birth height, age of standing up and standing and walking without support were analysed as predictors. Results: Of the individuals with SSD, only 11.2% were employed, although 77.6% remained not hospitalized. In individuals with SSD, only young maternal age was associated with lower probability (OR 0.25, CI 0.08–0.77) of being non-hospitalized after controlling for sex and onset age of illness. Among persons without SSD, almost all parenthood-related and developmental factors were related to employment, while grand multiparity and parental psychosis were related to hospitalization after controlling for sex. Conclusions: Only one of the early parenthood-related and developmental factors analysed in this study predicted outcome in individuals with SSD, while among those without SSD almost all factors were related to employment. Thus, prognosis of SSD does not seem to be predetermined much by early development. see all
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| Series: |
Schizophrenia research |
| ISSN: | 0920-9964 |
| ISSN-E: | 1573-2509 |
| ISSN-L: | 0920-9964 |
| Volume: | 173 |
| Issue: | 1-2 |
| DOI: | 10.1016/j.schres.2016.02.038 |
| OADOI: | https://oadoi.org/10.1016/j.schres.2016.02.038 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3112 Neurosciences |
| Subjects: | |
| Funding: |
This research was supported in part by grants from the Academy of Finland [#132071, #268336, #278286], the Sigrid Jusélius Foundation, the Jalmari and Rauha Ahokas Foundation, the Northern Finland Health Care Support Foundation, the Brain and Behavior Research Foundation and European Union's Horizon 2020 research and innovation programme under grant agreement No 643552. |
| EU Grant Number: |
(643552) m-RESIST - Mobile Therapeutic Attention for Patients with Treatment Resistant Schizophrenia |
| Academy of Finland Grant Number: |
132071 268336 278286 |
| Detailed Information: |
132071 (Academy of Finland Funding decision) 268336 (Academy of Finland Funding decision) 278286 (Academy of Finland Funding decision) |
| Copyright information: |
© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |