University of Oulu

Juha Käkelä, Riikka Marttila, Emmi Keskinen, Juha Veijola, Matti Isohanni, Heli Koivumaa-Honkanen, Marianne Haapea, Erika Jääskeläinen, Jouko Miettunen, Association between family history of psychiatric disorders and long-term outcome in schizophrenia – The Northern Finland Birth Cohort 1966 study, Psychiatry Research, Volume 249, 2017, Pages 16-22, ISSN 0165-1781,

Association between family history of psychiatric disorders and long-term outcome in schizophrenia : the Northern Finland Birth Cohort 1966 study

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Author: Käkelä, Juha1,2,3; Marttila, Riikka2,3; Keskinen, Emmi1,2,3;
Organizations: 1Research Unit of Clinical Neuroscience, Department of Psychiatry, University of Oulu, Oulu, Finland
2Center for Life Course Health Research, University of Oulu, Oulu, Finland
3Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
4Department of Psychiatry, Oulu University Hospital, Oulu, Finland
5Institute of Clinical Medicine, Psychiatry, University of Eastern Finland, Kuopio, Finland
6Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland
7South-Savonia Hospital District, Mikkeli, Finland
8North Karelia Central Hospital, Joensuu, Finland
9SOSTERI, Savonlinna, Finland
10SOTE, Iisalmi, Finland
11Lapland Hospital District, Rovaniemi, Finland
12Oulu Occupational Health, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.4 MB)
Persistent link:
Language: English
Published: Elsevier, 2017
Publish Date: 2017-12-27


Family history of psychiatric disorders has been associated with impaired outcome in schizophrenia, but very few studies have investigated its long-term social and occupational outcome. We investigated the association of family history of psychiatric disorders, especially psychosis, with long-term social, occupational, clinical and global outcome in schizophrenia. The study sample comprises of the Northern Finland Birth Cohort 1966. Cohort members with psychosis were detected by Finnish national registers. Altogether 69 individuals with schizophrenia spectrum diagnosis participated, mean age 43, after on average 17 years since onset of illness. The information regarding family history of psychiatric disorders were gathered from registers and interviews. A Strauss-Carpenter Outcome Scale, PANSS and SOFAS were conducted to assess the outcome. Results showed that the family history of any psychiatric disorder was associated with more severe positive and emotional symptoms in PANSS. The family history of psychosis was not associated with outcomes. These findings suggest that family history of psychiatric disorders has a small association with outcome in schizophrenia. Despite family history of psychosis being a strong risk factor for schizophrenia, after years of illness it does not seem to affect outcome.

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Series: Psychiatry research
ISSN: 0165-1781
ISSN-E: 1872-7123
ISSN-L: 0165-1781
Volume: 249
Pages: 16 - 22
DOI: 10.1016/j.psychres.2016.12.040
Type of Publication: A1 Journal article – refereed
Field of Science: 3112 Neurosciences
Funding: This study has been funded by the Academy of Finland (#268336, #278286), The Brain and Behavior Research Foundation, the Sigrid Jusélius Foundation, European Union's Horizon 2020 Research and Innovation Programme under grant agreement no 643552, and the Northern Finland Health Care Support Foundation. The funders had no role in the design or conduct of the study.
EU Grant Number: (643552) m-RESIST - Mobile Therapeutic Attention for Patients with Treatment Resistant Schizophrenia
Academy of Finland Grant Number: 268336
Detailed Information: 268336 (Academy of Finland Funding decision)
278286 (Academy of Finland Funding decision)
Copyright information: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license