University of Oulu

Lehtovirta, M., Pahkala, K., Niinikoski, H., Kangas, A., Soininen, P., Lagström, H., Viikari, J., Rönnemaa, T., Jula, A., Ala-Korpela, M., Würtz, P., Raitakari, O. (2018) Effect of Dietary Counseling on a Comprehensive Metabolic Profile from Childhood to Adulthood. Journal of Pediatrics, 195 (), 190-198.e3. doi:10.1016/j.jpeds.2017.11.057

Effect of dietary counseling on a comprehensive metabolic profile from childhood to adulthood

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Author: Lehtovirta, Miia1; Pahkala, Katja1; Niinikoski, Harri2;
Organizations: 1Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
2Department of Pediatrics and Adolescent Medicine, Turku University Hospital
3Computational Medicine, Faculty of Medicine, University of Oulu & Biocenter Oulu
4Department of Public Health, University of Turku
5Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital
6National Institute for Health and Welfare
7Medical Research Council Integrative Epidemiology Unit at the University of Bristol
8NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland
9Population Health Science, Bristol Medical School, University of Bristol
10Systems Epidemiology, Baker Heart and Diabetes Institute
11Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, The Alfred Hospital, Monash University
12Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.8 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2018051424128
Language: English
Published: Elsevier, 2018
Publish Date: 2018-05-14
Description:

Abstract

Objectives: To study the effects of repeated, infancy-onset dietary counseling on a detailed metabolic profile. Effects of dietary saturated fat replacement on circulating concentrations of metabolic biomarkers still remain unknown.

Study design: The Special Turku Coronary Risk Factor Intervention Project (STRIP) study is a longitudinal, randomized atherosclerosis prevention trial in which repeated dietary counseling aimed at reducing the proportion of saturated fat intake. Nuclear magnetic resonance metabolomics quantified circulating metabolites from serum samples assessed at age 9 (n = 554), 11 (n = 553), 13 (n = 508), 15 (n = 517), 17 (n = 457), and 19 (n = 417) years.

Results: The intervention reduced dietary intake of saturated fat (mean difference in daily percentage of total energy intake: −2.1 [95% CI −1.9 to −2.3]) and increased intake of polyunsaturated fat (0.6 [0.5-0.7]). The dietary counseling intervention led to greater serum proportions of polyunsaturated fatty acids (P < .001), with greater proportions of both circulating omega-3 (P = .02) and omega-6 (P < .001) fatty acids. The proportion of saturated fatty acids in serum was lower for both boys and girls in the intervention group (P < .001), whereas the serum proportion of monounsaturated fat was lower for boys in the intervention group only (P < .001). The intervention also reduced circulating intermediate-density lipoprotein and low-density lipoprotein lipid concentrations (P < .01). Dietary intervention effects on nonlipid biomarkers were minor except from greater concentrations of glutamine in the intervention group.

Conclusions: Repeated dietary counseling from infancy to early adulthood yielded favorable effects on multiple circulating fatty acids and lipoprotein subclass lipids, particularly in boys. These molecular effects substantiate the beneficial role of saturated fat replacement on the metabolic risk profile.

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Series: The journal of pediatrics
ISSN: 0022-3476
ISSN-E: 1097-6833
ISSN-L: 0022-3476
Volume: 195
Pages: 190 - 198.e3
DOI: 10.1016/j.jpeds.2017.11.057
OADOI: https://oadoi.org/10.1016/j.jpeds.2017.11.057
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 Internal medicine
3123 Gynaecology and paediatrics
Subjects:
Funding: Supported by Academy of Finland (206374, 294834, 251360, 275595); Juho Vainio Foundation; Finnish Cultural Foundation; Finnish Foundation for Cardiovascular Research; Sigrid Jusélius Foundation; Yrjö Jahnsson Foundation; Finnish Diabetes Research Foundation; Novo Nordisk Foundation; Strategic Research Funding from the University of Oulu, Finnish Ministry of Education and Culture; Special Governmental Grants for Health Sciences Research, Turku University Hospital; and University of Turku Foundation. A.K. works in a unit that receives funds from the University of Bristol and UK Medical Research Council (MC_UU_12013/1).
Academy of Finland Grant Number: 206374
294834
251360
275595
Detailed Information: 206374 (Academy of Finland Funding decision)
294834 (Academy of Finland Funding decision)
251360 (Academy of Finland Funding decision)
275595 (Academy of Finland Funding decision)
Copyright information: © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  https://creativecommons.org/licenses/by/4.0/