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Extracellular interleukin‐17F has a protective effect in oral tongue squamous cell carcinoma |
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| Author: | Almahmoudi, Rabeia1; Salem, Abdelhakim1,2; Sieviläinen, Meri1; |
| Organizations: |
1Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland 2Department of Clinical Medicine, Clinicum, University of Helsinki, Helsinki, Finland 3Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland
4Department of Pathology, University of Helsinki, Helsinki, Finland
5Department of Allergy, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 6Department of Pathology, Fimlab Laboratories, Tampere University Hospital, Tampere, Finland 7Medical Research Centre, Oulu University Hospital, Oulu, Finland 8Department of Diagnostics and Oral Medicine, Research Group of Cancer Research and Translational Medicine, Medical Faculty, University of Oulu, Oulu, Finland |
| Format: | article |
| Version: | accepted version |
| Access: | embargoed |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2018060525300 |
| Language: | English |
| Published: |
John Wiley & Sons,
2018
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| Publish Date: | 2019-05-14 |
| Description: |
AbstractBackground: Oral tongue squamous cell carcinoma (SCC) is characterized by early metastasis and poor prognosis. Interleukin‐17F (IL‐17F) plays a protective role in many tumors. However, IL‐17F expression in oral tongue SCC tissue has not been investigated. Methods: Immunostaining of 83 oral tongue SCC specimens and blinded‐scoring were used to map IL‐17F expression, location, and distribution. Survival curves were constructed according to Kaplan‐Meier method. The Cox proportional hazard model was applied for univariate and multivariate survival analyses. Results: Mast cells are the major source of IL‐17F in oral tongue SCC. In multivariate analysis, only the extracellular mast cell‐derived IL‐17F at the tumor invasion front was associated with better disease‐specific survival in patients with all‐stages and early‐stages of oral tongue SCC. Conclusion: Extracellular mast cell‐derived IL‐17F is antitumorigenic in oral tongue SCC. It separates patients with early‐stage disease who are at high risk from patients who are at low risk. Furthermore, when analyzing tentative prognostic molecules, we conclude that in addition to the staining intensity, attention must be paid to the cellular source, distribution, and location of the molecule. see all
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| Series: |
Head & neck |
| ISSN: | 1043-3074 |
| ISSN-E: | 1097-0347 |
| ISSN-L: | 1043-3074 |
| Volume: | In press |
| DOI: | 10.1002/hed.25207 |
| OADOI: | https://oadoi.org/10.1002/hed.25207 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3122 Cancers |
| Subjects: | |
| Funding: |
The authors acknowledge the funders of this study: Sigrid Jusélius Foundation, the Cancer Society of Finland, Oulu University Hospital MRC grant, Emil Aaltonen Foundation, and Helsinki University Central Hospital Research Funds. |
| Copyright information: |
© 2018 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Almahmoudi R, Salem A, Sieviläinen M, et al. Extracellular interleukin‐17F has a protective effect in oral tongue squamous cell carcinoma. Head & Neck. 2018;00:1–11. https://doi.org/10.1002/hed.25207, which has been published in final form at https://doi.org/10.1002/hed.25207. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving." |