University of Oulu

Kakko, T. , Salo, T. and Siponen, M. K. (2018), Oral lichen sclerosus: a systematic review of reported cases and two new cases. Int J Dermatol, 57: 521-528. doi:10.1111/ijd.13870

Oral lichen sclerosus : a systematic review of reported cases and two new cases

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Author: Kakko, Tuomas1; Salo, Tuula2,3,4; Siponen, Maria K.2,5,6
Organizations: 1Institute of Dentistry, Faculty of Medicine, University of Oulu, Oulu, Finland
2Cancer and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland
3Department of Oral and Maxillofacial Diseases, University of Helsinki, Oulu, Finland
4Medical Research Center, Oulu University Hospital, Oulu, Finland
5Department of Oral and Maxillofacial Diseases, Kuopio University Hospital, Kuopio, Finland
6Institute of Dentistry, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2018060525317
Language: English
Published: John Wiley & Sons, 2018
Publish Date: 2019-01-04
Description:

Abstract

Lichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease with uncertain etiology. It occurs as white plaque‐like lesions mostly in the anogenital skin. Oral mucosal involvement is extremely rare. This study aims to summarize the features of published oral lichen sclerosus (OLS) and two new cases.

A systematic search of the English literature from 1955 to 2016 was performed in MEDLINE, Scopus, and Web of Science, and cross‐references were searched manually. Search phrases included “lichen sclerosus,” “mouth,” “oral,” “lip,” “palate,” “floor of mouth,” “tongue,” “gingiva,” “buccal mucosa,” and “mouth diseases.” Cases with clinical and histopathological confirmation of diagnosis of OLS were included.

A total of 41 (39 published and 2 new) histologically confirmed OLS cases were available. The median age of OLS patients was 31 years, and 66% of the patients were female. Most of the OLS lesions were asymptomatic. They were located in the labial mucosa (n = 20), lip (n = 15), buccal mucosa (n = 14), gingiva (n = 12), tongue (n = 12), and palate (n = 7).

OLS is rare and typically presents as asymptomatic, white, plaque‐like lesions. Malignant transformation of preexisting OLS has not been reported.

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Series: International journal of dermatology
ISSN: 0011-9059
ISSN-E: 1365-4632
ISSN-L: 0011-9059
Volume: 57
Issue: 5
Pages: 521 - 528
DOI: 10.1111/ijd.13870
OADOI: https://oadoi.org/10.1111/ijd.13870
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3122 Cancers
Subjects:
Copyright information: © 2017 The International Society of Dermatology. This is the peer reviewed version of the following article: Kakko, T. , Salo, T. and Siponen, M. K. (2018), Oral lichen sclerosus: a systematic review of reported cases and two new cases. Int J Dermatol, 57: 521-528. doi:10.1111/ijd.13870, which has been published in final form at https://doi.org/10.1111/ijd.13870. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.