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Kalantari N, Keshavarz Mohammadi N, Izadi P, Doaei S, Gholamalizadeh M, Eini-Zinab H, et al. (2018) A haplotype of three SNPs in FTO had a strong association with body composition and BMI in Iranian male adolescents. PLoS ONE 13(4): e0195589. https://doi.org/10.1371/journal.pone.0195589

A haplotype of three SNPs in FTO had a strong association with body composition and BMI in Iranian male adolescents

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Author: Kalantari, Naser1; Keshavarz Mohammadi, Nastaran2; Izadi, Pantea3;
Organizations: 1Department of community nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Department of public health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Department of Human Genetics, Department of human genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
5Student Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6Department of public health, School of Public Health, North Khorasan University of Medical Sciences, Bojnurd, Iran
7Research groups of Internal Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland
8Health Promotion and Education Department, Ministry of health & medical education, Tehran, Iran
9Department of Veterinary Medicine, School of Veterinary Medicine, Shiraz University of medical sciences, Shiraz, Iran
10Department of Human Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2018060625406
Language: English
Published: Public Library of Science, 2018
Publish Date: 2018-06-06
Description:

Abstract

Background: Single-nucleotide polymorphisms (SNPs), which are located in the first intron of the FTO gene, are reported to be associated with body weight and the body mass index (BMI). However, their effects on anthropometric measurements in adolescents are poorly understood.

Objective: This study aimed to investigate the association of three adjacent polymorphisms (rs9930506, rs9930501, & rs9932754) in the FTO gene with anthropometric indices in Iranian adolescent males.

Design: The participants comprised a total of 237 adolescent males who were recruited randomly from two high schools in Tehran, Iran. The DNA samples were genotyped for the FTO gene polymorphisms by DNA sequencing. BMI, body fat percentage (BF%), and body muscle percentage (BM%) were determined using a validated bioelectrical impedance analysis scale. The association of the FTO polymorphisms with weight, height, BMI, BF%, and BM% was investigated.

Results: A haplotype of rs9930506, rs9930501, and rs9932754 (GGT) in the first intron of the FTO with complete linkage disequilibrium (LD) was found to be significantly associated with higher weight (OR = 1.32), BMI (OR = 5.36) and BF% (OR = 1.46), and lower BM% (OR = 3.59) (all P<0.001). None of the students with GGC genotypes were underweight, while all of the students with AAT genotypes had high muscle mass.

Conclusions: A haplotype in the first intron of the FTO gene had a strong association with obesity indices in Iranian adolescent males. The FTO gene polymorphisms might have greater effects on anthropometric indices than what was previously imagined. Moreover, we suggested that the FTO gene exerted their effects on anthropometric measurements through haplotypes (and not single SNPs).

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Series: PLoS one
ISSN: 1932-6203
ISSN-E: 1932-6203
ISSN-L: 1932-6203
Volume: 13
Issue: 4
Article number: e0195589
DOI: 10.1371/journal.pone.0195589
OADOI: https://oadoi.org/10.1371/journal.pone.0195589
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
Subjects:
Article
Funding: This study was funded by Shahid Beheshti University of Medical Sciences and Health Education and Promotion (code 8237 to NK), Department of Ministry of Health, Tehran, Iran (code 2842 to NK). We acknowledge all the schools' staff for their excellent cooperation.
Copyright information: © 2018 Kalantari et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
  https://creativecommons.org/licenses/by/4.0/