Biterova, E., Esmaeeli, M., Alanen, H., Saaranen, M., Ruddock, L. (2018) Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease. Scientific Reports, 8 (1), . doi:10.1038/s41598-018-25237-7
Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease
|Author:||Biterova, Ekaterina1; Esmaeeli, Mariam1,2; Alanen, Heli I.1;|
11Faculty of Biochemistry and Molecular Biology and Biocenter Oulu, University of Oulu, Oulu, 90220, Finland
2Present address: Department of Molecular Enzymology, University of Potsdam, 14476, Potsdam, Germany
|Online Access:||PDF Full Text (PDF, 4.2 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2018060625413
|Publish Date:|| 2018-06-06
Coronary artery disease is the most common cause of death globally and is linked to a number of risk factors including serum low density lipoprotein, high density lipoprotein, triglycerides and lipoprotein(a). Recently two proteins, angiopoietin-like protein 3 and 4, have emerged from genetic studies as being factors that significantly modulate plasma triglyceride levels and coronary artery disease. The exact function and mechanism of action of both proteins remains to be elucidated, however, mutations in these proteins results in up to 34% reduction in coronary artery disease and inhibition of function results in reduced plasma triglyceride levels. Here we report the crystal structures of the fibrinogen-like domains of both proteins. These structures offer new insights into the reported loss of function mutations, the mechanisms of action of the proteins and open up the possibility for the rational design of low molecular weight inhibitors for intervention in coronary artery diseas
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
This work was supported by the Academy of Finland (grant numbers 266457 and 272573), Sigrid Juselius Foundation and Biocenter Oulu.
|Academy of Finland Grant Number:||
272573 (Academy of Finland Funding decision)
Supplementary information accompanies this paper at https://doi.org/10.1038/s41598-018-25237-7.
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