University of Oulu

Salem A, Almahmoudi R, Vehviläinen M, Salo T. Role of the high mobility group box 1 signalling axes via the receptor for advanced glycation end-products and toll-like receptor-4 in the immunopathology of oral lichen planus: a potential drug target? Eur J Oral Sci 2018; 126: 244–248. https://doi.org/10.1111/eos.12416

Role of the high mobility group box 1 signalling axes via the receptor for advanced glycation end-products and toll-like receptor-4 in the immunopathology of oral lichen planus

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Author: Salem, Abdelhakim1,2; Almahmoudi, Rabeia2; Vehviläinen, Mari3;
Organizations: 1Department of Clinical Medicine, Clinicum, University of Helsinki, Helsinki
2Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki
3Department of Social Services and Health Care, Unit for Specialized Oral Care in the Metropolitan Area and Kirkkonummi, Helsinki
4Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2018062126267
Language: English
Published: John Wiley & Sons, 2018
Publish Date: 2019-04-20
Description:

Abstract

High mobility group box 1 (HMGB1) is an extremely conserved DNA‐binding protein that stabilizes nucleosomes and facilitates gene transcription in mammalian cells. When released extracellularly, HMGB1 becomes an alarmin that can mediate systemic diseases. High mobility group box 1 signals via two main receptors: receptor for advanced glycation end‐products (RAGE) and toll‐like receptor‐4 (TLR4). We hypothesized that HMGB1 expression is increased in patients with oral lichen planus (OLP) relative to healthy controls. Therefore, HMGB1 and its receptors were mapped in tissue biopsies from 25 patients with OLP and from 20 healthy controls by immunostaining and ImageJ analysis. High mobility group box 1 was induced in oral keratinocytes in all patients with OLP. The band‐like cell infiltrate in patients with OLP revealed very strong staining for RAGE. Likewise, TLR4 was overexpressed throughout OLP mucosa which co‐localized with HMGB1. In conclusion, we suggest that OLP could partly be an HMGB1‐mediated condition by creating a proinflammatory loop cycle via RAGE‐ and TLR4‐signalling axes, which may contribute to the chronicity of this disease.

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Series: European journal of oral sciences
ISSN: 0909-8836
ISSN-E: 1600-0722
ISSN-L: 0909-8836
Volume: 126
Issue: 3
Pages: 244 - 248
DOI: 10.1111/eos.12416
OADOI: https://oadoi.org/10.1111/eos.12416
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
Subjects:
OLP
Copyright information: © 2018 Eur J Oral Sci. This is the peer reviewed version of the following article: Salem A, Almahmoudi R, Vehviläinen M, Salo T. Role of the high mobility group box 1 signalling axes via the receptor for advanced glycation end-products and toll-like receptor-4 in the immunopathology of oral lichen planus: a potential drug target? Eur J Oral Sci 2018; 126: 244–248, which has been published in final form at https://doi.org/10.1111/eos.12416. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.