University of Oulu

Mustaniemi, S., Vääräsmäki, M., Eriksson, J., Gissler, M., Laivuori, H., Ijäs, H., Bloigu, A., Kajantie, E., Morin-Papunen, L. (2018) Polycystic ovary syndrome and risk factors for gestational diabetes. Endocrine Connections, 7 (7), 859-869. doi:10.1530/EC-18-0076

Polycystic ovary syndrome and risk factors forngestational diabetes

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Author: Mustaniemi, Sanna1,2; Vääräsmäki, Marja1,2; Eriksson, Johan G3,4;
Organizations: 1Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland
2PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
3Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
4Folkhälsan Research Centre, Helsinki, Finland
5Information Services Department, National Institute for Health and Welfare, Helsinki, Finland
6Division of Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden
7Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
8Department of Obstetrics and Gynaecology, Tampere University Hospital, Tampere, Finland
9Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
10Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
11Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
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Language: English
Published: Bioscientifica, 2018
Publish Date: 2018-09-19


Objective: To study the roles of self-reported symptoms and/or prior diagnosis of polycystic ovary syndrome (PCOS) and other potential risk factors for gestational diabetes mellitus (GDM) and to clarify whether the screening of GDM in early pregnancy is beneficial for all women with PCOS.

Design: The FinnGeDi multicentre case-control study including 1146 women with singleton pregnancies diagnosed with GDM and 1066 non-diabetic pregnant women. There were 174 women with PCOS (symptoms and/or diagnosis self-reported by a questionnaire) and 1767 women without PCOS (data missing for 271).

Methods: The study population (N = 1941) was divided into four subgroups: GDM + PCOS (N = 105), GDM + non-PCOS (N = 909), non-GDM + PCOS (N = 69), and controls (N = 858). The participants’ characteristics and their parents’ medical histories were compared.

Results: The prevalence of PCOS was 10.4% among GDM women and 7.4% among nondiabetics (odds ratios (OR) 1.44, 95% CI: 1.05–1.97), but PCOS was not an independent risk for GDM after adjustments for participants’ age and pre-pregnancy BMI (OR 1.07, 95% CI: 0.74–1.54). In a multivariate logistic regression analysis, the most significant parameters associated with GDM were overweight, obesity, age ≥35 years, participant’s mother’s history of GDM, either parent’s history of type 2 diabetes (T2D) and participant’s own preterm birth.

Conclusions: The increased risk of GDM in women with PCOS was related to obesity and increased maternal age rather than to PCOS itself, suggesting that routine early screening of GDM in PCOS women without other risk factors should be reconsidered. Instead, family history of GDM/T2D and own preterm birth were independent risk factors for GDM.

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Series: Endocrine connections
ISSN: 2049-3614
ISSN-E: 2049-3614
ISSN-L: 2049-3614
Volume: 7
Issue: 7
Pages: 859 - 869
DOI: 10.1530/EC-18-0076
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
Funding: This work was supported by Academy of Finland (grant numbers 127437, 128929, 129306, 130326, 134791, 274794); Foundation for Pediatric Research; Diabetes Research Foundation; Juho Vainio Foundation; Novo Nordisk Foundation; Signe and Ane Gyllenberg Foundation; Sigrid Jusélius Foundation and Yrjö Jahnsson Foundation.
Copyright information: © 2018 The authors. Published by Bioscientifica Ltd. This work is licensed under a Creative Commons Attribution 4.0 International License.