|
|
Habitual coffee consumption and cognitive function : a Mendelian randomization meta-analysis in up to 415,530 participants |
|---|---|
| Author: | Zhou, Ang1; Taylor, Amy E.2,3; Karhunen, Ville4,5; |
| Organizations: |
1Australian Centre for Precision Health, University of South Australia 2MRC Integrative Epidemiology Unit (IEU) at the University of Bristol 3UK Centre for Tobacco and Alcohol Studies (UKCTAS) and School of Experimental Psychology, University of Bristol
4Center for Life Course Health Research, University of Oulu
5Oulu University Hospital 6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet 7Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku 8Helsinki Collegium for Advanced Studies 9Department of Psychology and Logopedics, Faculty of medicine, University of Helsinki 10Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University 11Department of Surgical Sciences, Orthopaedics, Uppsala University 12Institute of Health & Wellbeing, University of Glasgow 13Unit of Primary Health Care, Oulu University Hospital 14Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Life Sciences, University of Tampere 15Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere 16Department of Pediatrics, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere 17Department of Public Health Solutions, National Institute for Health and Welfare 18Wellcome Centre for Human Genetics, Nuffield Department of Medicine, Oxford 19Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University 20Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health 21Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital 22Folkhälsan Research Center 23Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital 24Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu 25Department of Psychiatry, University Hospital of Oulu 26Department of Epidemiology and Biostatistics, MRC–PHE Centre for Environment & Health, School of Public Health, Imperial College London 27Biocenter Oulu, University of Oulu 28Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine 29Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University 30Stanford Cardiovascular Institute, Stanford University 31University of Exeter Medical School 32South Australian Health and Medical Research Institute |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1.5 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2018080933566 |
| Language: | English |
| Published: |
Springer Nature,
2018
|
| Publish Date: | 2018-08-09 |
| Description: |
AbstractCoffee’s long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian randomization to investigate the causal relationship between habitual coffee consumption and cognitive function in mid- to later life. This included up to 415,530 participants and 300,760 coffee drinkers from 10 meta-analysed European ancestry cohorts. In each cohort, composite cognitive scores that capture global cognition and memory were computed using available tests. A genetic score derived using CYP1A1/2 (rs2472297) and AHR (rs6968865) was chosen as a proxy for habitual coffee consumption. Null associations were observed when examining the associations of the genetic score with global and memory cognition (β = −0.0007, 95% C.I. −0.009 to 0.008, P = 0.87; β = −0.001, 95% C.I. −0.005 to 0.002, P = 0.51, respectively), with high consistency between studies (Pheterogeneity > 0.4 for both). Domain specific analyses using available cognitive measures in the UK Biobank also did not support effects by habitual coffee intake for reaction time, pairs matching, reasoning or prospective memory (P ≥ 0.05 for all). Despite the power to detect very small effects, our meta-analysis provided no evidence for causal long-term effects of habitual coffee consumption on global cognition or memory. see all
|
| Series: |
Scientific reports |
| ISSN: | 2045-2322 |
| ISSN-E: | 2045-2322 |
| ISSN-L: | 2045-2322 |
| Volume: | 8 |
| Article number: | 7526 |
| DOI: | 10.1038/s41598-018-25919-2 |
| OADOI: | https://oadoi.org/10.1038/s41598-018-25919-2 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3142 Public health care science, environmental and occupational health |
| Subjects: | |
| Funding: |
This study was financially supported by J.J. Mason and H.S. Williams Memorial Foundation CT23158. For full acknowledgement and study specific funding information, see the supplementary materials. |
| Dataset Reference: |
Electronic supplementary material: |
|
https://static-content.springer.com/esm/art%3A10.1038%2Fs41598-018-25919-2/MediaObjects/41598_2018_25919_MOESM1_ESM.docx |
|
| Copyright information: |
© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
|
https://creativecommons.org/licenses/by/4.0/ |