University of Oulu

Zhou, A., Taylor, A., Karhunen, V., Zhan, Y., Rovio, S., Lahti, J., Sjögren, P., Byberg, L., Lyall, D., Auvinen, J., Lehtimäki, T., Kähönen, M., Hutri-Kähönen, N., Perälä, M., Michaëlsson, K., Mahajan, A., Lind, L., Power, C., Eriksson, J., Raitakari, O., Hägg, S., Pedersen, N., Veijola, J., Järvelin, M., Munafò, M., Ingelsson, E., Llewellyn, D., Hyppönen, E. (2018) Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants. Scientific Reports, 8 (1). doi:10.1038/s41598-018-25919-2

Habitual coffee consumption and cognitive function : a Mendelian randomization meta-analysis in up to 415,530 participants

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Author: Zhou, Ang1; Taylor, Amy E.2,3; Karhunen, Ville4,5;
Organizations: 1Australian Centre for Precision Health, University of South Australia
2MRC Integrative Epidemiology Unit (IEU) at the University of Bristol
3UK Centre for Tobacco and Alcohol Studies (UKCTAS) and School of Experimental Psychology, University of Bristol
4Center for Life Course Health Research, University of Oulu
5Oulu University Hospital
6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
7Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
8Helsinki Collegium for Advanced Studies
9Department of Psychology and Logopedics, Faculty of medicine, University of Helsinki
10Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University
11Department of Surgical Sciences, Orthopaedics, Uppsala University
12Institute of Health & Wellbeing, University of Glasgow
13Unit of Primary Health Care, Oulu University Hospital
14Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Life Sciences, University of Tampere
15Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere
16Department of Pediatrics, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere
17Department of Public Health Solutions, National Institute for Health and Welfare
18Wellcome Centre for Human Genetics, Nuffield Department of Medicine, Oxford
19Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University
20Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health
21Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital
22Folkhälsan Research Center
23Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital
24Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu
25Department of Psychiatry, University Hospital of Oulu
26Department of Epidemiology and Biostatistics, MRC–PHE Centre for Environment & Health, School of Public Health, Imperial College London
27Biocenter Oulu, University of Oulu
28Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
29Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University
30Stanford Cardiovascular Institute, Stanford University
31University of Exeter Medical School
32South Australian Health and Medical Research Institute
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.5 MB)
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Language: English
Published: Springer Nature, 2018
Publish Date: 2018-08-09


Coffee’s long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian randomization to investigate the causal relationship between habitual coffee consumption and cognitive function in mid- to later life. This included up to 415,530 participants and 300,760 coffee drinkers from 10 meta-analysed European ancestry cohorts. In each cohort, composite cognitive scores that capture global cognition and memory were computed using available tests. A genetic score derived using CYP1A1/2 (rs2472297) and AHR (rs6968865) was chosen as a proxy for habitual coffee consumption. Null associations were observed when examining the associations of the genetic score with global and memory cognition (β = −0.0007, 95% C.I. −0.009 to 0.008, P = 0.87; β = −0.001, 95% C.I. −0.005 to 0.002, P = 0.51, respectively), with high consistency between studies (Pheterogeneity > 0.4 for both). Domain specific analyses using available cognitive measures in the UK Biobank also did not support effects by habitual coffee intake for reaction time, pairs matching, reasoning or prospective memory (P ≥ 0.05 for all). Despite the power to detect very small effects, our meta-analysis provided no evidence for causal long-term effects of habitual coffee consumption on global cognition or memory.

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Series: Scientific reports
ISSN: 2045-2322
ISSN-E: 2045-2322
ISSN-L: 2045-2322
Volume: 8
Article number: 7526
DOI: 10.1038/s41598-018-25919-2
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
Funding: This study was financially supported by J.J. Mason and H.S. Williams Memorial Foundation CT23158. For full acknowledgement and study specific funding information, see the supplementary materials.
Dataset Reference: Electronic supplementary material:
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