University of Oulu

King, J., Fallorina, A., Yu, J., Zhang, G., Telkki, V., Hilty, C., Meldrum, T. (2018) Probing molecular dynamics with hyperpolarized ultrafast Laplace NMR using a low-field, single-sided magnet. Chemical Science, 9 (28), 6143-6149. doi:10.1039/C8SC01329B

Probing molecular dynamics with hyperpolarized ultrafast Laplace NMR using a low-field, single-sided magnet

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Author: King, Jared N.1; Fallorina, Alfredo1; Yu, Justin1;
Organizations: 1Department of Chemistry, The College of William & Mary, Williamsburg, Virginia 23187-8795, USA
2Present addresses: Department of Chemistry, Duke University; Durham, North Carolina 27708, USA
3Department of Chemistry, Texas A&M University, 3255 TAMU, College Station, Texas 77843, USA
4NMR Research Unit, Faculty of Science, University of Oulu, 90014 Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2018080933590
Language: English
Published: Royal Society of Chemistry, 2018
Publish Date: 2018-08-09
Description:

Abstract

Laplace NMR (LNMR) offers deep insights on diffusional and rotational motion of molecules. The so-called “ultrafast” approach, based on spatial data encoding, enables one to carry out a multidimensional LNMR experiment in a single scan, providing from 10 to 1000-fold acceleration of the experiment. Here, we demonstrate the feasibility of ultrafast diffusion–T₂ relaxation correlation (DT₂) measurements with a mobile, low-field, relatively low-cost, single-sided NMR magnet. We show that the method can probe a broad range of diffusion coefficients (at least from 10⁻⁸ to 10⁻¹² m² s⁻¹) and reveal multiple components of fluids in heterogeneous materials. The single-scan approach is demonstrably compatible with nuclear spin hyperpolarization techniques because the time-consuming hyperpolarization process does not need to be repeated. Using dynamic nuclear polarization (DNP), we improved the NMR sensitivity of water molecules by a factor of 10⁵ relative to non-hyperpolarized NMR in the 0.3 T field of the single-sided magnet. This enabled us to acquire a DT₂ map in a single, 22 ms scan, despite the low field and relatively low mole fraction (0.003) of hyperpolarized water. Consequently, low-field, hyperpolarized ultrafast LNMR offers significant prospects for advanced, mobile, low-cost and high-sensitivity chemical and medical analysis.

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Series: Chemical science
ISSN: 2041-6520
ISSN-E: 2041-6539
ISSN-L: 2041-6520
Volume: 9
Issue: 28
Pages: 6143 - 6149
DOI: 10.1039/c8sc01329b
OADOI: https://oadoi.org/10.1039/c8sc01329b
Type of Publication: A1 Journal article – refereed
Field of Science: 114 Physical sciences
116 Chemical sciences
Subjects:
Funding: We acknowledge the generous support provided by the European Research Council (ERC) under Horizon 2020 (H2020/2018–2022/ERC grant agreement no. 772110) and the Academy of Finland (grant numbers 289649 and 294027), the Welch Foundation (Grant A-1658), the National Science Foundation (Grant CHE-1362691) and the Ji and Li Family Foundation.
EU Grant Number: (772110) UFLNMR - Ultrafast Laplace NMR
Academy of Finland Grant Number: 289649
294027
Detailed Information: 289649 (Academy of Finland Funding decision)
294027 (Academy of Finland Funding decision)
Copyright information: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
  https://creativecommons.org/licenses/by/3.0/